The Novel Chinese Medicine JY5 Formula Alleviates Hepatic Fibrosis by Inhibiting the Notch Signaling Pathway
| العنوان: | The Novel Chinese Medicine JY5 Formula Alleviates Hepatic Fibrosis by Inhibiting the Notch Signaling Pathway |
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| المؤلفون: | Yadong Fu, Zhun Xiao, Xiaoting Tian, Wei Liu, Zhou Xu, Tao Yang, Yonghong Hu, Xiaoxi Zhou, Jing Fang, Siqi Gao, Dingqi Zhang, Yongping Mu, Hua Zhang, Yiyang Hu, Chenggang Huang, Jiamei Chen, Ping Liu |
| المصدر: | Frontiers in Pharmacology, Vol 12 (2021) Frontiers in Pharmacology |
| بيانات النشر: | Frontiers Media S.A., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Pharmacology, Cirrhosis, biology, Chemistry, notch signaling pathway, Notch signaling pathway, JY5 formula, RM1-950, biology.organism_classification, medicine.disease, Salvia miltiorrhiza, fuzheng huayu, traditional Chinese medicine, In vivo, Hepatic stellate cell, medicine, Pharmacology (medical), hepatic fibrosis, Gynostemma pentaphyllum, Therapeutics. Pharmacology, Cell activation, Hepatic fibrosis, Original Research |
| الوصف: | Advanced liver fibrosis can lead to cirrhosis, resulting in an accelerated risk of hepatocellular carcinoma and liver failure. Fuzheng Huayu formula (FZHY) is a traditional Chinese medicine formula treated liver fibrosis in China approved by a Chinese State Food and Drug Administration (NO: Z20050546), composed of Salvia Miltiorrhiza bge., Prunus davidiana (Carr.) Franch., cultured Cordyceps sinensis (BerK.) Sacc. Mycelia, Schisandra chinensis (Turcz.) Baill., Pinus massoniana Lamb., and Gynostemma pentaphyllum (Thunb.) Makino. However, the main active substances and mechanism of FZHY are unclear. The aim of this study is to identify a novel anti-fibrotic compound, which consists of the main active ingredients of FZHY, and investigate its mechanism of pharmacological action. The main active ingredients of FZHY were investigated by quantitative analysis of FZHY extracts and FZHY-treated plasma and liver in rats. The anti-fibrotic composition of the main active ingredients was studied through uniform design in vivo, and its mechanism was evaluated in carbon tetrachloride (CCl4)- and bile duct ligation (BDL)-induced liver fibrosis models in rats and mice, and transforming growth factor beta 1-induced LX-2 cell activation model in vitro. A novel Chinese medicine, namely JY5 formula, consisting of salvianolic acid B, schisantherin A, and amygdalin, the main active ingredients of FZHY, significantly alleviated hepatic hydroxyproline content and collagen deposition in CCl4-and BDL-induced fibrotic liver in rats and mice. In addition, JY5 inhibited the activation of hepatic stellate cells (HSCs) by inactivating Notch signaling in vitro and in vivo. In this study, we found a novel JY5 formula, which exerted anti-hepatic fibrotic effects by inhibiting the Notch signaling pathway, consequently suppressing HSCs activation. These results provide an adequate scientific basis for clinical research and application of the JY5 formula, which may be a potential novel therapeutic candidate for liver fibrosis. |
| اللغة: | English |
| تدمد: | 1663-9812 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9681a786a7ff98127e0a8fbc9ce5093fTest https://www.frontiersin.org/articles/10.3389/fphar.2021.671152/fullTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9681a786a7ff98127e0a8fbc9ce5093f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16639812 |
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