التفاصيل البيبلوغرافية
| العنوان: |
Controversial Role of the Immune Checkpoint OX40L Expression on Platelets in Breast Cancer Progression. |
| المؤلفون: |
Rittig, Susanne M., Lutz, Martina S., Clar, Kim L., Yanjun Zhou, Kropp, Korbinian N., Koch, André, Hartkopf, Andreas D., Hinterleitner, Martina, Zender, Lars, Salih, Helmut R., Maurer, Stefanie, Hinterleitner, Clemens |
| المصدر: |
Frontiers in Oncology; 7/8/2022, Vol. 12, p1-10, 10p, 3 Graphs |
| مستخلص: |
In conventional T cells, OX40 has been identified as a major costimulating receptor augmenting survival and clonal expansion of effector and memory T cell populations. In regulatory T cells, (Treg) OX40 signaling suppresses cellular activity and differentiation. However, clinical trials investigating OX40 agonists to enhance anti-tumor immunity, showed only limited success so far. Here we show that platelets from breast cancer patients express relevant levels of OX40L and platelet OX40L (pOX40L) inversely correlates with platelet-expressed immune checkpoint molecules GITRL (pGITRL) and TACI (pTACI). While high expression of pOX40L correlates with T and NK cell activation, elevated pOX40L levels identify patients with higher tumor grades, the occurrence of metastases, and shorter recurrence-free survival (RFS). Of note, OX40 mRNA levels in breast cancer correlate with enhanced expression of anti-apoptotic, immunesuppressive, and tumor-promoting mRNA gene signatures. Our data suggest that OX40L on platelets might play counteracting roles in cancer and anti-tumor immunity. Since pOX40L reflects disease relapse better than the routinely used predictive markers CA15-3, CEA, and LDH, it could serve as a novel biomarker for refractory disease in breast cancer. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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