A Predictor Combining Clinical and Genetic Factors for AML1-ETO Leukemia Patients
| العنوان: | A Predictor Combining Clinical and Genetic Factors for AML1-ETO Leukemia Patients |
|---|---|
| المؤلفون: | Min Yang, Bide Zhao, Jinghan Wang, Yi Zhang, Chao Hu, Lixia Liu, Jiayue Qin, Feng Lou, Shanbo Cao, Chengcheng Wang, Wenjuan Yu, Hongyan Tong, Haitao Meng, Jian Huang, Honghu Zhu, Jie Jin |
| المصدر: | Frontiers in Oncology, Vol 11 (2022) Frontiers in Oncology |
| بيانات النشر: | Frontiers Media S.A., 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Cancer Research, Oncology, hemic and lymphatic diseases, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, next-generation sequencing, AML-ETO, prognosis, acute myeloid leukemia, LASSO Cox regression, RC254-282, Original Research |
| الوصف: | Core Binding Factor (CBF)-AML is one of the most common somatic mutations in acute myeloid leukemia (AML). t(8;21)/AML1-ETO-positive acute myeloid leukemia accounts for 5-10% of all AMLs. In this study, we consecutively included 254 AML1-ETO patients diagnosed and treated at our institute from December 2009 to March 2020, and evaluated molecular mutations by 185-gene NGS platform to explore genetic co-occurrences with clinical outcomes. Our results showed that high KIT VAF(≥15%) correlated with shortened overall survival compared to other cases with no KIT mutation (3-year OS rate 26.6% vs 59.0% vs 69.6%, HR 1.50, 95%CI 0.78-2.89, P=0.0005). However, no difference was found in patients’ OS whether they have KIT mutation in two or three sites. Additionally, we constructed a risk model by combining clinical and molecular factors; this model was validated in other independent cohorts. In summary, our study showed that c-kit other than any other mutations would influence the OS in AML1-ETO patients. A proposed predictor combining both clinical and genetic factors is applicable to prognostic prediction in AML1-ETO patients. |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d21ae5bacd8d38a53726a89714d4087Test https://www.frontiersin.org/articles/10.3389/fonc.2021.783114/fullTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9d21ae5bacd8d38a53726a89714d4087 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |