PD-L1 Expression on Tumor Cells Is Associated With a Poor Outcome in a Cohort of Caucasian Nasopharyngeal Carcinoma Patients
| العنوان: | PD-L1 Expression on Tumor Cells Is Associated With a Poor Outcome in a Cohort of Caucasian Nasopharyngeal Carcinoma Patients |
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| المؤلفون: | Thorsten Fuereder, Christoph Krall, Gabriela Kornek, Leonhard Müllauer, Felicitas Oberndorfer, Christina Wagner, Christoph Minichsdorfer |
| المصدر: | Frontiers in Oncology, Vol 9 (2019) Frontiers in Oncology |
| بيانات النشر: | Frontiers Media SA, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | PD-L1, 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Population, lcsh:RC254-282, 03 medical and health sciences, 0302 clinical medicine, LAG-3, Internal medicine, PD-1, Medicine, education, Original Research, education.field_of_study, biology, Tumor-infiltrating lymphocytes, business.industry, nasopharyngeal carcinoma, Hazard ratio, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, Confidence interval, Log-rank test, 030104 developmental biology, Nasopharyngeal carcinoma, 030220 oncology & carcinogenesis, Cohort, biology.protein, Caucasian population, business |
| الوصف: | Background: Nasopharyngeal carcinoma (NPC) is endemic in East Asia but rare in the western world. Programmed death ligand 1 (PD-L1) expression on NPC correlates with clinical outcomes. However, data for Caucasian NPC patients are missing. Thus, we performed this retrospective analysis for investigating the potential association of immune checkpoint protein expression with outcome parameters in Caucasian NPC patients.Methods: Fifty-five patients with NPC treated between 1993 and 2018 at the Medical University of Vienna were identified. After the exclusion of Asian patients, data on baseline demographic, tumor stage, overall survival (OS), and disease-free survival (DFS) of 30 patients were analyzed. Their tumor samples were stained and scored (low vs. high) for PD-L1, programmed death receptor 1 (PD-1), lymphocyte activating gene 3 (LAG3), and cluster of differentiation 8 (CD8) antibodies. Statistical analysis was performed with Kaplan-Meier plots and log-rank test. Estimated hazard ratios of dichotomized analysis were calculated, together with 95% confidence intervals and p-values of Wald tests.Results: PD-L1 expression was ≥50% in 6 (20%) patients, whereas 19 (63%) had ≥1% expression and 5 (17%) tumor samples were PD-L1-negative. While sex and age had no impact on DFS or OS |
| تدمد: | 2234-943X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da1e624e5450e2db09042ac5b9da677cTest https://doi.org/10.3389/fonc.2019.01334Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....da1e624e5450e2db09042ac5b9da677c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2234943X |
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