التفاصيل البيبلوغرافية
| العنوان: |
Liver fibrosis and retinal features in an older Mediterranean population: Results from the Salus in Apulia study |
| المؤلفون: |
Lampignano, Luisa, Niro, Alfredo, Castellana, Fabio, Bortone, Ilaria, Zupo, Roberta, Tirelli, Sarah, Tatoli, Rossella, Griseta, Chiara, De Nucci, Sara, Sila, Annamaria, De Pergola, Giovanni, Conte, Caterina, Alessio, Giovanni, Boscia, Francesco, Sborgia, Giancarlo, Giannelli, Gianluigi, Sardone, Rodolfo |
| المصدر: |
Frontiers in Neuroscience ; volume 16 ; ISSN 1662-453X |
| بيانات النشر: |
Frontiers Media SA |
| سنة النشر: |
2022 |
| المجموعة: |
Frontiers (Publisher - via CrossRef) |
| مصطلحات موضوعية: |
General Neuroscience |
| الوصف: |
Background Age is a leading contributor to the liver fibrosis rate and a gradual deterioration of optical function, but this association in older populations is still under-explored. The present study aimed to explore the link between vascular and neural retinal characteristics and the risk of liver fibrosis in 731 older adults from the population-based Salus in Apulia study. Methods Retinal features were obtained using optical coherence tomography (OCT) and OCT-angiography (OCT-A). Liver fibrosis risk was taken as the fibrosis-4 (FIB-4) score. Generalized linear models (logistic regression) were used to estimate the association effect between each unit increase of OCT and OCT-A parameters as independent variables and a FIB-4 ≥ 2.67 score as an outcome. Generalized additive models were used to assess the non-linear association between OCT-A features and the linear FIB-4 score. Results Increased gangliar cell complex (GCC) thickness was inversely associated with a FIB-4 score above the cut-off in both the raw model (OR: 0.98; 95% CI: 0.96–0.99; SE: 0.01) and after adjustment for age, sex, education, hypertension, diabetes, total cholesterol, and triglycerides (OR: 0.98; 95% CI: 0.97–0.99; SE: 0.01). Conclusion Our findings add to the growing volume of scientific literature demonstrating that liver fibrosis is associated with retinal neurodegeneration. This study raises a number of new questions, including whether OCT-A may be used to track the progression of metabolic abnormalities and define exact thresholds for predicting and classifying liver disease. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| DOI: |
10.3389/fnins.2022.1048375 |
| DOI: |
10.3389/fnins.2022.1048375/full |
| الإتاحة: |
https://doi.org/10.3389/fnins.2022.1048375Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.34A19EFA |
| قاعدة البيانات: |
BASE |
