Evolution and Comparative Physiology of Luqin-Type Neuropeptide Signaling
| العنوان: | Evolution and Comparative Physiology of Luqin-Type Neuropeptide Signaling |
|---|---|
| المؤلفون: | Luis Alfonso Yañez-Guerra, Maurice R. Elphick |
| المصدر: | Frontiers in Neuroscience, Vol 14 (2020) Frontiers in Neuroscience |
| بيانات النشر: | Frontiers Media S.A., 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, RWamides, Starfish, Neuropeptide, Lymnaea stagnalis, neuropeptide evolution, Review, lcsh:RC321-571, 03 medical and health sciences, 0302 clinical medicine, luqin, RYamides, Bilateria, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, G protein-coupled receptor, Deuterostome, biology, General Neuroscience, Asterias, biology.organism_classification, 030104 developmental biology, G-protein coupled receptors, Evolutionary biology, Aplysia, cardio-excitatory peptide, 030217 neurology & neurosurgery, Neuroscience |
| الوصف: | Luqin is a neuropeptide that was discovered and named on account of its expression in left upper quadrant cells of the abdominal ganglion in the mollusc Aplysia californica. Subsequently, luqin-type peptides were identified as cardio-excitatory neuropeptides in other molluscs and a cognate receptor was discovered in the pond snail Lymnaea stagnalis. Phylogenetic analyses have revealed that orthologs of molluscan luqin-type neuropeptides occur in other phyla; these include neuropeptides in ecdysozoans (arthropods, nematodes) that have a C-terminal RYamide motif (RYamides) and neuropeptides in ambulacrarians (echinoderms, hemichordates) that have a C-terminal RWamide motif (RWamides). Furthermore, precursors of luqin-type neuropeptides typically have a conserved C-terminal motif containing two cysteine residues, although the functional significance of this is unknown. Consistent with the orthology of the neuropeptides and their precursors, phylogenetic and pharmacological studies have revealed that orthologous G-protein coupled receptors (GPCRs) mediate effects of luqin-type neuropeptides in spiralians, ecdysozoans, and ambulacrarians. Luqin-type signaling originated in a common ancestor of the Bilateria as a paralog of tachykinin-type signaling but, unlike tachykinin-type signaling, luqin-type signaling was lost in chordates. This may largely explain why luqin-type signaling has received less attention than many other neuropeptide signaling systems. However, insights into the physiological actions of luqin-type neuropeptides (RYamides) in ecdysozoans have been reported recently, with roles in regulation of feeding and diuresis revealed in insects and roles in regulation of feeding, egg laying, locomotion, and lifespan revealed in the nematode Caenorhabditis elegans. Furthermore, characterization of a luqin-type neuropeptide in the starfish Asterias rubens (phylum Echinodermata) has provided the first insights into the physiological roles of luqin-type signaling in a deuterostome. In conclusion, although luqin was discovered in Aplysia over 30 years ago, there is still much to be learnt about luqin-type neuropeptide signaling. This will be facilitated in the post-genomic era by the emerging opportunities for experimental studies on a variety of invertebrate taxa. |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31e37d12cbe6480c9e5fd9fdb1374b07Test https://www.frontiersin.org/article/10.3389/fnins.2020.00130/fullTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....31e37d12cbe6480c9e5fd9fdb1374b07 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |