التفاصيل البيبلوغرافية
| العنوان: |
Botulinum neurotoxin type A in the interdisciplinary treatment of sialorrhea in adults and children—update and practice recommendations |
| المؤلفون: |
Jost, Wolfgang H., Bäumer, Tobias, Bevot, Andrea, Birkmann, Ulrich, Buhmann, Carsten, Grosheva, Maria, Guntinas-Lichius, Orlando, Laskawi, Rainer, Paus, Sebastian, Pflug, Christina, Schroeder, A. Sebastian, Spittau, Björn, Steffen, Armin, Wilken, Bernd, Winterholler, Martin, Berweck, Steffen |
| المصدر: |
Frontiers in Neurology ; volume 14 ; ISSN 1664-2295 |
| بيانات النشر: |
Frontiers Media SA |
| سنة النشر: |
2023 |
| المجموعة: |
Frontiers (Publisher - via CrossRef) |
| مصطلحات موضوعية: |
Neurology (clinical), Neurology |
| الوصف: |
Sialorrhea is defined as a chronic excessive flow of saliva from the mouth, often with adverse consequences for health and quality of life of patients. In addition to currently used non-drug treatment and systemic drugs, intraglandular Botulinum Neurotoxin A (BoNT/A) injections have been examined in case studies, controlled trials and clinical practice. Two pivotal Phase III trials recently led to market approval in the USA and EU for IncobotulinumtoxinA [Xeomin®, IncoBoNT/A, Clostridium botulinum neurotoxin type A (150 kD), free from complexing proteins, Merz Pharmaceuticals GmbH] for treatment of chronic sialorrhea in adults and pediatric patients. This review provides a multidisciplinary approach to discuss the current state of sialorrhea therapy as well as benefits and current limitations of BoNT/A injections. A consensus regarding treatment recommendations made available to physicians in Germany in 2022 has now been updated here for presentation to an international audience. This review provides a framework including a flow chart for patient selection, recommendations for dosing and the injection process, as well as a discussion of therapeutic goals, long-term benefits and safety aspects. This review is aimed at supporting physicians in developing multidisciplinary and individualized treatment approaches to achieve optimal benefits for patients. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| DOI: |
10.3389/fneur.2023.1275807 |
| DOI: |
10.3389/fneur.2023.1275807/full |
| الإتاحة: |
https://doi.org/10.3389/fneur.2023.1275807Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.D6799ABA |
| قاعدة البيانات: |
BASE |
