المؤلفون: Ratnadurai-Giridharan, Shivakeshavan, Stefanescu, Roxana A, Khargonekar, Pramod P, Carney, Paul R, Talathi, Sachin S

المصدر: Frontiers in neural circuits. 8

مصطلحات موضوعية: Neurons, Animals, Rats, Rats, Sprague-Dawley, Seizures, Bicuculline, Action Potentials, Models, Neurological, Computer Simulation, Male, CA1 Region, Hippocampal, computational models, hippocampal CA1 region, interictal spikes, paroxysmal depolarization shift, temporal lobe epilepsy

الوصف: Interictal spikes (IISs) are spontaneous high amplitude, short time duration 80%) receives a barrage of quasi-synchronous afferent input (input occurring within a temporal window of ≤24 ms) via the SC. However, as we increase the recurrent connectivity of the CA1 (P sprout > 40); mimicking sprouting in a pathological CA1 network, the CA1 can exhibit IIS even in the absence of a barrage of quasi-synchronous afferents from the SC (input occurring within temporal window >80 ms) and a low fraction of CA1 Py cells (≈30%) receiving SC input. Furthermore, we find that in the presence of Poisson distributed random input via SC, the CA1 network is able to generate spontaneous periodic IISs (≈3 Hz) for high degrees of recurrent Py connectivity (P sprout > 70). We investigate the conditions necessary for this phenomenon and find that spontaneous IISs closely depend on the degree of the network's intrinsic excitability.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/6kw1009kTest

المؤلفون: Shivakeshavan eRatnadurai Giridharan, Roxana A Stefanescu, Pramod P Khargonekar, Paul R Carney, Sachin S Talathi

المصدر: Frontiers in Neural Circuits
Ratnadurai-Giridharan, S; Stefanescu, RA; Khargonekar, PP; Carney, PR; & Talathi, SS. (2014). Genesis of interictal spikes in the CA1: a computational investigation. FRONTIERS IN NEURAL CIRCUITS, 8. doi: 10.3389/fncir.2014.00002. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/6kw1009kTest
BASE-Bielefeld Academic Search Engine
BMC Neuroscience, Vol 13, Iss Suppl 1, p P30 (2012)
Frontiers in Neural Circuits, Vol 8 (2014)
BMC Neuroscience

مصطلحات موضوعية: computational modeling, Male, Computer science, Cognitive Neuroscience, Models, Neurological, Neuroscience (miscellaneous), Action Potentials, hippocampal CA1 region, Time duration, paroxysmal depolarization shift, Bicuculline, Rats sprague dawley, lcsh:RC321-571, Rats, Sprague-Dawley, Cellular and Molecular Neuroscience, Text mining, Seizures, Afferent, Animals, Ictal, Computer Simulation, Original Research Article, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, CA1 Region, Hippocampal, Physics, Neurons, High amplitude, business.industry, Paroxysmal depolarizing shift, musculoskeletal, neural, and ocular physiology, General Neuroscience, lcsh:QP351-495, interictal spikes, temporal lobe epilepsy, Data science, EPILEPSY TEMPORAL LOBE, Sensory Systems, Rats, lcsh:Neurophysiology and neuropsychology, Epilepsy, Temporal Lobe, nervous system, computational models, Poster Presentation, business, Neuroscience

الوصف: Interictal spikes (IISs) are spontaneous high amplitude, short time duration 80%) receives a barrage of quasi-synchronous afferent input (input occurring within a temporal window of ≤24 ms) via the SC. However, as we increase the recurrent connectivity of the CA1 (Psprout > 40); mimicking sprouting in a pathological CA1 network, the CA1 can exhibit IIS even in the absence of a barrage of quasi-synchronous afferents from the SC (input occurring within temporal window >80 ms) and a low fraction of CA1 Py cells (≈30%) receiving SC input. Furthermore, we find that in the presence of Poisson distributed random input via SC, the CA1 network is able to generate spontaneous periodic IISs (≈3 Hz) for high degrees of recurrent Py connectivity (Psprout > 70). We investigate the conditions necessary for this phenomenon and find that spontaneous IISs closely depend on the degree of the network's intrinsic excitability.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5c99e9ea276232bbbb3201c6ae11727Test
https://pubmed.ncbi.nlm.nih.gov/24478636Test