التفاصيل البيبلوغرافية
| العنوان: |
Radiological Characteristics of Patients With Anti-MDA5–Antibody-Positive Dermatomyositis in 18F-FDG PET/CT: A Pilot Study |
| المؤلفون: |
Cao, Heng, Liang, Junyu, Xu, Danyi, Liu, Yinuo, Yao, Yinan, Sun, Yiduo, He, Ye, Lin, Jin |
| المساهمون: |
National Natural Science Foundation of China |
| المصدر: |
Frontiers in Medicine ; volume 8 ; ISSN 2296-858X |
| بيانات النشر: |
Frontiers Media SA |
| سنة النشر: |
2021 |
| المجموعة: |
Frontiers (Publisher - via CrossRef) |
| الوصف: |
Objective: To elucidate the 18 F-fluorodeoxyglucose (FDG) PET/CT characteristics and its prognostic value in the patients with anti-melanoma differentiation associated protein 5 antibody positive (anti-MDA5+) dermatomyositis (DM). Methods: This retrospective cross-sectional study included 26 patients with anti-MDA5+ DM and 43 patients with anti-MDA5 negative (anti-MDA5–) idiopathic inflammatory myopathy (IIM) who were examined by 18 F-FDG PET/CT from January 1, 2017 to December 31, 2020. The maximum standardized uptake value (SUVmax) of multiple organs and other clinical characteristics of the patients were measured and analyzed. Results: Compared with the anti-MDA5– group, the patients in the anti-MDA5+ group showed higher bilateral lung SUVmax ( p = 0.029), higher SUVmax of spleen ( p = 0.011), and bone marrow ( p = 0.048). Significant correlations between the spleen SUVmax and serum ferritin levels ( r = 0.398, p < 0.001), erythrocyte sedimentation rate (ESR) ( r = 0.274, p = 0.023), platelet count ( r = −0.265, p = 0.028), myositis disease activity assessment score ( r = 0.332, p = 0.005), bone marrow SUVmax ( r = 0.564, p < 0.001), and bilateral lung SUVmax ( r = 0.393, p < 0.001) were observed. Conclusion: 18 F-FDG PET/CT was found valuable in quantifying the pulmonary focal inflammation and potentially unveil the distinctive characteristics and pathophysiological mechanisms in the patients with anti-MDA5+ DM. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| DOI: |
10.3389/fmed.2021.779272 |
| DOI: |
10.3389/fmed.2021.779272/full |
| الإتاحة: |
https://doi.org/10.3389/fmed.2021.779272Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.B9EE8782 |
| قاعدة البيانات: |
BASE |
