التفاصيل البيبلوغرافية
| العنوان: |
Abatacept increases T cell exhaustion in early RA individuals who carry HLA risk alleles |
| المؤلفون: |
Long, Sarah Alice, Muir, Virginia S., Jones, Britta E., Wall, Valerie Z., Ylescupidez, Alyssa, Hocking, Anne M., Pribitzer, Stephan, Thorpe, Jerill, Fuchs, Bryce, Wiedeman, Alice E., Tatum, Megan, Lambert, Katharina, Uchtenhagen, Hannes, Speake, Cate, Ng, Bernard, Heubeck, Alexander T., Torgerson, Troy R., Savage, Adam K., Maldonado, Michael A., Ray, Neelanjana, Khaychuk, Vadim, Liu, Jinqi, Linsley, Peter S., Buckner, Jane H. |
| المصدر: |
Frontiers in Immunology ; volume 15 ; ISSN 1664-3224 |
| بيانات النشر: |
Frontiers Media SA |
| سنة النشر: |
2024 |
| المجموعة: |
Frontiers (Publisher - via CrossRef) |
| مصطلحات موضوعية: |
Immunology, Immunology and Allergy |
| الوصف: |
Exhausted CD8 T cells (T EX ) are associated with worse outcome in cancer yet better outcome in autoimmunity. Building on our past findings of increased TIGIT + KLRG1 + T EX with teplizumab therapy in type 1 diabetes (T1D), in the absence of treatment we found that the frequency of TIGIT + KLRG1 + T EX is stable within an individual but differs across individuals in both T1D and healthy control (HC) cohorts. This TIGIT + KLRG1 + CD8 T EX population shares an exhaustion-associated EOMES gene signature in HC, T1D, rheumatoid arthritis (RA), and cancer subjects, expresses multiple inhibitory receptors, and is hyporesponsive in vitro , together suggesting co-expression of TIGIT and KLRG1 may broadly define human peripheral exhausted cells. In HC and RA subjects, lower levels of EOMES transcriptional modules and frequency of TIGIT + KLRG1 + T EX were associated with RA HLA risk alleles (DR0401, 0404, 0405, 0408, 1001) even when considering disease status and cytomegalovirus (CMV) seropositivity. Moreover, the frequency of TIGIT + KLRG1 + T EX was significantly increased in RA HLA risk but not non-risk subjects treated with abatacept (CTLA4Ig). The DR4 association and selective modulation with abatacept suggests that therapeutic modulation of T EX may be more effective in DR4 subjects and T EX may be indirectly influenced by cellular interactions that are blocked by abatacept. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| DOI: |
10.3389/fimmu.2024.1383110 |
| DOI: |
10.3389/fimmu.2024.1383110/full |
| الإتاحة: |
https://doi.org/10.3389/fimmu.2024.1383110Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.EB7669BA |
| قاعدة البيانات: |
BASE |
