Tryptophan feeding of the IDO1-AhR axis in host-microbial symbioses
| العنوان: | Tryptophan feeding of the IDO1-AhR axis in host-microbial symbioses |
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| المؤلفون: | Silvia Moretti, Rossana G. Iannitti, Antonella De Luca, Marco Gargaro, Luigina Romani, Teresa Zelante, Andrea Bartoli, Francesca Fallarino |
| المصدر: | Frontiers in Immunology, Vol 5 (2014) Frontiers in Immunology |
| بيانات النشر: | Frontiers Media S.A., 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | lcsh:Immunologic diseases. Allergy, Immunology, Resistance, Biology, indoleamine-2, aryl hydrocarbon receptor, indoleamine-2,3-dioxygenase, microbial symbiosis, resistance, tolerance, 03 medical and health sciences, 0302 clinical medicine, Immune system, Symbiosis, Transcription (biology), Immunology and Allergy, Immune homeostasis, Indoleamine 2,3-dioxygenase, Aryl hydrocarbon receptor, 030304 developmental biology, Genetics, 0303 health sciences, Tryptophan, Human microbiome, Opinion Article, respiratory system, respiratory tract diseases, Cell biology, 3-dioxygenase, 030220 oncology & carcinogenesis, biology.protein, indoleamine 2, lcsh:RC581-607 |
| الوصف: | The large variety of microbial species in the human microbiome plays an important role in human health by affecting tissue differentiation, modulation of the immune system, as well as the general response against infectious pathogens. The aryl hydrocarbon receptor (AhR) contributes to immune homeostasis as having an antimicrobial role on the one hand ‐ owing to AhR-dependent IL-22 transcription ‐ and, on the other, an anti-inflammatory role in that it mediates the differentiation of regulatory T cells (Tregs). Here, we have examined the multifaceted physiological role of AhR as resulting from the vast array of recently described AhR ligands and of the multiplicity of AhR-expressing cells in host-microbial symbiosis in mammals. |
| اللغة: | English |
| تدمد: | 1664-3224 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b82899c08b2348717d1e1d121568859Test http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00640/fullTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0b82899c08b2348717d1e1d121568859 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16643224 |
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