Efficacy and Effect of Inhaled Adenosine Treatment in Hospitalized COVID-19 Patients
| العنوان: | Efficacy and Effect of Inhaled Adenosine Treatment in Hospitalized COVID-19 Patients |
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| المؤلفون: | Massimo Caracciolo, Pierpaolo Correale, Carmelo Mangano, Giuseppe Foti, Carmela Falcone, Sebastiano Macheda, Maria Cuzzola, Marco Conte, Antonella Consuelo Falzea, Eleonora Iuliano, Antonella Morabito, Michele Caraglia, Nicola Polimeni, Anna Ferrarelli, Demetrio Labate, Marco Tescione, Laura Di Renzo, Gaetano Chiricolo, Lorenzo Romano, Antonino De Lorenzo |
| المساهمون: | Caracciolo, M., Correale, P., Mangano, C., Foti, G., Falcone, C., Macheda, S., Cuzzola, M., Conte, M., Falzea, A. C., Iuliano, E., Morabito, A., Caraglia, M., Polimeni, N., Ferrarelli, A., Labate, D., Tescione, M., Di Renzo, L., Chiricolo, G., Romano, L., De Lorenzo, A. |
| المصدر: | Frontiers in Immunology, Vol 12 (2021) Frontiers in Immunology |
| بيانات النشر: | Frontiers Media SA, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Adenosine, Azithromycin, Settore MED/49, Gastroenterology, Lopinavir, 0302 clinical medicine, Enzyme Inhibitor, Immunology and Allergy, Medicine, 030212 general & internal medicine, Enzyme Inhibitors, Tomography, Original Research, Mortality rate, Middle Aged, Prognosis, Pathophysiology, Anti-Bacterial Agents, X-Ray Computed, Hospitalization, Female, medicine.symptom, Case-Control Studie, Cytokine Release Syndrome, Cytochrome P-450 CYP3A Inhibitor, Human, Hydroxychloroquine, medicine.drug, lcsh:Immunologic diseases. Allergy, Adult, medicine.medical_specialty, Prognosi, Immunology, Inflammation, COVID-19, SARS-CoV-2, Length of stay, Aged, Case-Control Studies, Cytochrome P-450 CYP3A Inhibitors, Heparin, Humans, Tomography, X-Ray Computed, 03 medical and health sciences, Pharmacotherapy, Immune system, Internal medicine, Anti-Bacterial Agent, business.industry, Case-control study, medicine.disease, COVID-19 Drug Treatment, 030104 developmental biology, lcsh:RC581-607, business, Cytokine storm |
| الوصف: | Lack of specific antiviral treatment for COVID-19 has resulted in long hospitalizations and high mortality rate. By harnessing the regulatory effects of adenosine on inflammatory mediators, we have instituted a new therapeutic treatment with inhaled adenosine in COVID-19 patients, with the aim of reducing inflammation, the onset of cytokine storm, and therefore to improve prognosis. The use of inhaled adenosine in COVID19 patients has allowed reduction of length of stay, on average 6 days. This result is strengthened by the decrease in SARS-CoV-2 positive days. In treated patients compared to control, a clear improvement in PaO2/FiO2 was observed together with a reduction in inflammation parameters, such as the decrease of CRP level. Furthermore, the efficacy of inhaled exogenous adenosine led to an improvement of the prognosis indices, NLR and PLR. The treatment seems to be safe and modulates the immune system, allowing an effective response against the viral infection progression, reducing length of stay and inflammation parameters. |
| تدمد: | 1664-3224 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0295fa627a2422b810291ad5dcf68687Test https://doi.org/10.3389/fimmu.2021.613070Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0295fa627a2422b810291ad5dcf68687 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16643224 |
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