The NLRP3 Inflammasome Is Upregulated in HIV-Infected Antiretroviral Therapy-Treated Individuals with Defective Immune Recovery

التفاصيل البيبلوغرافية
العنوان: The NLRP3 Inflammasome Is Upregulated in HIV-Infected Antiretroviral Therapy-Treated Individuals with Defective Immune Recovery
المؤلفون: Alessandra Bandera, Michela Masetti, Massimiliano Fabbiani, Mara Biasin, Antonio Muscatello, Nicola Squillace, Mario Clerici, Andrea Gori, Daria Trabattoni
المصدر: Frontiers in Immunology
Frontiers in Immunology, Vol 9 (2018)
سنة النشر: 2017
مصطلحات موضوعية: 0301 basic medicine, lcsh:Immunologic diseases. Allergy, Adult, Male, Anti-HIV Agents, Inflammasomes, caspase, Immunology, Caspase 3, HIV Infections, Peripheral blood mononuclear cell, 03 medical and health sciences, Mice, Immune system, Immune Reconstitution, Downregulation and upregulation, inflammasome, NLR Family, Pyrin Domain-Containing 3 Protein, Immunology and Allergy, Medicine, Animals, Humans, Caspase, Aged, Original Research, IFI16, biology, business.industry, pyroptosis, Caspase 1, Pyroptosis, HIV, Inflammasome, Middle Aged, 030112 virology, Up-Regulation, 030104 developmental biology, Cross-Sectional Studies, Treatment Outcome, Case-Control Studies, biology.protein, HIV-1, Leukocytes, Mononuclear, RNA, Viral, Female, business, lcsh:RC581-607, medicine.drug
الوصف: Background Inflammasome-mediated activation of caspase-1 regulates inflammatory responses and pyroptosis. We analyzed possible associations between inflammasome-related genes and immune reconstitution in HIV-infected antiretroviral therapy (ART)-treated patients. Methods Cross-sectional, case–control study. HIV-infected patients on ART for ≥24 months with HIV-RNA
تدمد: 1664-3224
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ec2be2233b4bd5722e6adad6dfc05e2Test
https://pubmed.ncbi.nlm.nih.gov/29483915Test
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....6ec2be2233b4bd5722e6adad6dfc05e2
قاعدة البيانات: OpenAIRE