Bactericidal/Permeability-Increasing Protein Is an Enhancer of Bacterial Lipoprotein Recognition
| العنوان: | Bactericidal/Permeability-Increasing Protein Is an Enhancer of Bacterial Lipoprotein Recognition |
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| المؤلفون: | Bülow, Sigrid, Zeller, Lisa, Werner, Maren, Toelge, Martina, Holzinger, Jonas, Entzian, Clemens, Schubert, Thomas, Waldow, Franziska, Gisch, Nicolas, Hammerschmidt, Sven, Gessner, André |
| المصدر: | Frontiers in Immunology, Vol 9 (2018) Frontiers in Immunology |
| بيانات النشر: | Frontiers Media S.A., 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Lipopolysaccharides, Male, lcsh:Immunologic diseases. Allergy, Lipoproteins, Immunology, 610 Medizin, Gram-Positive Bacteria, Meningitis, Bacterial, Lipopeptides, Gram-positive, Bacterial Proteins, bactericidal/permeability-increasing protein, bacterial lipoprotein, Immunology and Allergy, Humans, Gram-Positive Bacterial Infections, Original Research, bactericidal/permeability-increasing protein, pro-inflammatory, bacterial lipoprotein, lipoteichoic acid, Streptococcus pneumoniae, Gram-positive, pattern recognition, ddc:610, Tumor Necrosis Factor-alpha, pattern recognition, Blood Proteins, humanities, pro-inflammatory, Teichoic Acids, lipoteichoic acid, HEK293 Cells, Streptococcus pneumoniae, Leukocytes, Mononuclear, lcsh:RC581-607, psychological phenomena and processes, Antimicrobial Cationic Peptides |
| الوصف: | Adequate perception of immunologically important pathogen-associated molecular patterns like lipopolysaccharide and bacterial lipoproteins is essential for efficient innate and adaptive immune responses. In the context of Gram-negative infection, bactericidal/permeability-increasing protein (BPI) neutralizes endotoxic activity of lipopolysaccharides, and thus prohibits hyperactivation. So far, no immunological function of BPI has been described in Gram-positive infections. Here, we show a significant elevation of BPI in Gram-positive meningitis and, surprisingly, a positive correlation between BPI and pro-inflammatory markers like TNF alpha. To clarify the underlying mechanisms, we identify BPI ligands of Gram-positive origin, specifically bacterial lipopeptides and lipoteichoic acids, and determine essential structural motifs for this interaction. Importantly, the interaction of BPI with these newly defined ligands significantly enhances the immune response in peripheral blood mononuclear cells (PBMCs) mediated by Gram-positive bacteria, and thereby ensures their sensitive perception. In conclusion, we define BPI as an immune enhancing pattern recognition molecule in Gram-positive infections. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1664-3224 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd029b109062c119e231f61add2f6a2dTest https://www.frontiersin.org/article/10.3389/fimmu.2018.02768/fullTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fd029b109062c119e231f61add2f6a2d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16643224 |
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