التفاصيل البيبلوغرافية
| العنوان: |
SARS CoV-2 Spike Protein in silico Interaction With ACE2 Receptors From Wild and Domestic Species |
| المؤلفون: |
Rendon-Marin, Santiago, Martinez-Gutierrez, Marlen, Whittaker, Gary R., Jaimes, Javier A., Ruiz-Saenz, Julian |
| المصدر: |
Frontiers in Genetics ; volume 12 ; ISSN 1664-8021 |
| بيانات النشر: |
Frontiers Media SA |
| سنة النشر: |
2021 |
| المجموعة: |
Frontiers (Publisher - via CrossRef) |
| مصطلحات موضوعية: |
Genetics (clinical), Genetics, Molecular Medicine |
| الوصف: |
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been declared a pandemic by the World Health Organization (WHO), and since its first report, it has become a major public health concern. SARS-CoV-2 is closely related to SARS-CoV and SARS-related bat coronaviruses, and it has been described to use angiotensin-converting enzyme 2 (ACE2) as a receptor. Natural SARS-CoV-2 infection in domestic and wildlife animals, measured by RT-qPCR, has been confirmed in different countries, especially from the Felidae family. In silico analysis of the interaction between the SARS-CoV-2 spike protein and the cellular receptor ACE2 in various animal species has suggested that wild felids and domestic cats could be susceptible to SARS-CoV-2 based on this interaction. Here, we performed a protein-protein molecular docking analysis of SARS-CoV-2 spike protein with the ACE2 receptor from different animals to elucidate the potential of those species as intermediate hosts or susceptible animals for SARS-CoV-2 infection. Compared to human ACE2, we found that ACE2 receptors from domestic cats and tigers could efficiently interact with RBD of SARS CoV-2 Spike protein. However, dog, ferret, and hamster ACE2 receptor interaction with SARS-CoV-2 S protein RBD was not predicted as favorable, demonstrating a potential differentiated susceptibility in the evaluated species. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| DOI: |
10.3389/fgene.2021.571707 |
| DOI: |
10.3389/fgene.2021.571707/full |
| الإتاحة: |
https://doi.org/10.3389/fgene.2021.571707Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.FCD0D56E |
| قاعدة البيانات: |
BASE |
