Macrophage Activation Marker Neopterin: A Candidate Biomarker for Treatment Response and Relapse in Visceral Leishmaniasis
| العنوان: | Macrophage Activation Marker Neopterin: A Candidate Biomarker for Treatment Response and Relapse in Visceral Leishmaniasis |
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| المؤلفون: | Anke E. Kip, Monique Wasunna, Fabiana Alves, Jan H. M. Schellens, Jos H. Beijnen, Ahmed M. Musa, Eltahir A. G. Khalil, Thomas P. C. Dorlo |
| المساهمون: | Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology |
| المصدر: | Frontiers in cellular and infection microbiology, 8. Frontiers Media S.A. Frontiers in Cellular and Infection Microbiology, Vol 8 (2018) |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, lcsh:QR1-502, Gastroenterology, lcsh:Microbiology, chemistry.chemical_compound, Recurrence, Multicenter Studies as Topic, visceral leishmaniasis, liposomal amphotericin B, Child, Neopterin, Middle Aged, kala-azar, Drug Combinations, Treatment Outcome, Infectious Diseases, Leishmaniasis, Visceral, Biomarker (medicine), biomarker, Female, miltefosine, medicine.drug, Adult, Microbiology (medical), medicine.medical_specialty, Adolescent, Combination therapy, Phosphorylcholine, 030106 microbiology, Immunology, Sensitivity and Specificity, Microbiology, Young Adult, 03 medical and health sciences, macrophage activation, Amphotericin B, Internal medicine, medicine, pharmacodynamics, Humans, Miltefosine, Surrogate endpoint, business.industry, medicine.disease, Kenya, Clinical trial, Kinetics, 030104 developmental biology, Visceral leishmaniasis, chemistry, neopterin, Pharmacodynamics, business, Biomarkers |
| الوصف: | The Leishmania parasite resides and replicates within host macrophages during visceral leishmaniasis (VL). This study aimed to evaluate neopterin, a marker of macrophage activation, as possible pharmacodynamic biomarker to monitor VL treatment response and to predict long-term clinical relapse of VL. Following informed consent, 497 plasma samples were collected from East-African VL patients receiving a 28-day miltefosine monotherapy (48 patients) or 11-day combination therapy of miltefosine and liposomal amphotericin B (L-AMB, 48 patients). Neopterin was quantified with ELISA. Values are reported as median (inter-quartile range). Baseline neopterin concentrations were elevated in all VL patients at 98.8 (63.9–135) nmol/L compared to reported levels for healthy controls ( |
| وصف الملف: | image/pdf |
| اللغة: | English |
| تدمد: | 2235-2988 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d26d9a90d25fe6bf27e536f85c867a8Test https://doi.org/10.3389/fcimb.2018.00181Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8d26d9a90d25fe6bf27e536f85c867a8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22352988 |
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