التفاصيل البيبلوغرافية
| العنوان: |
Roles of airway and intestinal epithelia in responding to pathogens and maintaining tissue homeostasis. |
| المؤلفون: |
Ambrogi, Marcela, Vezina, Chad M. |
| المصدر: |
Frontiers in Cellular & Infection Microbiology; 2024, p1-25, 25p |
| مصطلحات موضوعية: |
INTESTINAL mucosa, HOMEOSTASIS, EPITHELIAL cells, REGULATORY T cells, STEM cells, EPITHELIUM, SMALL intestine |
| مستخلص: |
Epithelial cells form a resilient barrier and orchestrate defensive and reparative mechanisms to maintain tissue stability. This review focuses on gut and airway epithelia, which are positionedwhere the body interfaces with the outside world. We review themany signaling pathways andmechanisms by which epithelial cells at the interface respond to invading pathogens to mount an innate immune response and initiate adaptive immunity and communicate with other cells, including resident microbiota, to heal damaged tissue and maintain homeostasis. We compare and contrast how airway and gut epithelial cells detect pathogens, release antimicrobial effectors, collaborate withmacrophages, Tregs and epithelial stem cells tomount an immune response and orchestrate tissue repair. We also describe advanced research models for studying epithelial communication and behaviors during inflammation, tissue injury and disease. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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