Characterizing the Invasive Tumor Front of Aggressive Uterine Adenocarcinoma and Leiomyosarcoma
| العنوان: | Characterizing the Invasive Tumor Front of Aggressive Uterine Adenocarcinoma and Leiomyosarcoma |
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| المؤلفون: | Sabina Sanegre, Núria Eritja, Carlos de Andrea, Juan Diaz-Martin, Ángel Diaz-Lagares, María Amalia Jácome, Carmen Salguero-Aranda, David García Ros, Ben Davidson, Rafel Lopez, Ignacio Melero, Samuel Navarro, Santiago Ramon y Cajal, Enrique de Alava, Xavier Matias-Guiu, Rosa Noguera |
| المساهمون: | Institut Català de la Salut, [Sanegre S] Cancer CIBER (CIBERONC), Madrid, Spain. Department of Pathology, School of Medical, University of Valencia-INCLIVA, Valencia, Spain. [Eritja N] Cancer CIBER (CIBERONC), Madrid, Spain. Institut de Recerca Biomèdica de LLeida (IRBLLEIDA), Institut d’Investigació Biomèdica de Bellvitge (IDIBELL), Department of Pathology, Hospital U Arnau de Vilanova and Hospital U de Bellvitge, University of Lleida - University of Barcelona, Barcelona, Spain. [de Andrea C] Cancer CIBER (CIBERONC), Madrid, Spain. Clínica Universidad de Navarra, University of Navarra, Pamplona, Spain. [Diaz-Martin J] Cancer CIBER (CIBERONC), Madrid, Spain. Institute of Biomedicine of Sevilla, Virgen del Rocio University Hospital/CSIC/University of Sevilla/CIBERONC, Seville, Spain. [Diaz-Lagares Á] Cancer CIBER (CIBERONC), Madrid, Spain. Cancer Epigenomics, Translational Medical Oncology Group (Oncomet), Health Research Institute of Santiago (IDIS), University Clinical Hospital of Santiago (CHUS/SERGAS), Santiago de Compostela, Spain. [Jácome MA] Department of Mathematics, MODES Group, CITIC, Faculty of Science, Universidade da Coruña, A Coruña, Spain. [Ramon Y Cajal S] Cancer CIBER (CIBERONC), Madrid, Spain. Servei de Patologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain, Vall d'Hebron Barcelona Hospital Campus, Instituto de Salud Carlos III, European Commission, Centro de Investigación Biomédica en Red Cáncer (España), Asociación Española Contra el Cáncer |
| المصدر: | Frontiers in Cell and Developmental Biology, Vol 9 (2021) Dipòsit Digital de la UB Universidad de Barcelona Scientia Digital.CSIC. Repositorio Institucional del CSIC instname Repositorio Abierto de la UdL Universitad de Lleida Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona RUC. Repositorio da Universidade da Coruña Frontiers in Cell and Developmental Biology Dadun. Depósito Académico Digital de la Universidad de Navarra r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA |
| بيانات النشر: | Frontiers Media S.A., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Leiomyosarcoma, Reticular fiber, reticular fibers, Úter - Tumors, QH301-705.5, Músculs - Càncer, neoplasias::neoplasias por localización::neoplasias urogenitales::neoplasias de los genitales femeninos::neoplasias uterinas [ENFERMEDADES], extracellular matrix, factores biológicos::biomarcadores::marcadores tumorales [COMPUESTOS QUÍMICOS Y DROGAS], Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Genital Neoplasms, Female::Uterine Neoplasms [DISEASES], Biology, Metastasis, Cell and Developmental Biology, Immune system, neoplasias::neoplasias por tipo histológico::neoplasias de tejido conjuntivo y de tejidos blandos::neoplasias de tejido muscular::leiomiosarcoma [ENFERMEDADES], Càncer d'úter, immune cells, Tumor-host interface, Metàstasi, medicine, Uterine cancer, Neoplasms::Neoplasms by Histologic Type::Neoplasms, Connective and Soft Tissue::Neoplasms, Muscle Tissue::Leiomyosarcoma [DISEASES], tumor microenvironment, Biological Factors::Biomarkers::Biomarkers, Tumor [CHEMICALS AND DRUGS], Biology (General), epigenetic profiles, Microdissection, Antimicrobial humoral response, Original Research, Tumor microenvironment, Marcadors tumorals, Immune cells, Epigenetic profiles, Cell Biology, Extracellular matrix, medicine.disease, Epigenètica, Reticular connective tissue, Cancer research, gene expression, Epigenetics, Gene expression, This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), Reticular fibers, tumor-host interface, Developmental Biology |
| الوصف: | The invasive tumor front (the tumor–host interface) is vitally important in malignant cell progression and metastasis. Tumor cell interactions with resident and infiltrating host cells and with the surrounding extracellular matrix and secreted factors ultimately determine the fate of the tumor. Herein we focus on the invasive tumor front, making an in-depth characterization of reticular fiber scaffolding, infiltrating immune cells, gene expression, and epigenetic profiles of classified aggressive primary uterine adenocarcinomas (24 patients) and leiomyosarcomas (11 patients). Sections of formalin-fixed samples before and after microdissection were scanned and studied. Reticular fiber architecture and immune cell infiltration were analyzed by automatized algorithms in colocalized regions of interest. Despite morphometric resemblance between reticular fibers and high presence of macrophages, we found some variance in other immune cell populations and distinctive gene expression and cell adhesion-related methylation signatures. Although no evident overall differences in immune response were detected at the gene expression and methylation level, impaired antimicrobial humoral response might be involved in uterine leiomyosarcoma spread. Similarities found at the invasive tumor front of uterine adenocarcinomas and leiomyosarcomas could facilitate the use of common biomarkers and therapies. Furthermore, molecular and architectural characterization of the invasive front of uterine malignancies may provide additional prognostic information beyond established prognostic factors. This research was supported by grants from the ISCIII and ERDF (PI17/01558 and PI20/01107), by the CIBERONC (contracts CB16/12/00484, CB16/12/0328, CB16/12/00363, CB16/12/00364, CB16/12/00481, and CB16/12/00231) and Grupos Coordinados Estables from the Asociación Española Contra el Cáncer (AECC). ÁD-L was funded by a contract “Juan Rodés” from the ISCIII (JR17/00016). |
| وصف الملف: | application/pdf; image/jpeg |
| اللغة: | English |
| تدمد: | 2296-634X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ca09424dc40c469d734031ac1a02a07Test https://www.frontiersin.org/articles/10.3389/fcell.2021.670185/fullTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1ca09424dc40c469d734031ac1a02a07 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2296634X |
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