المؤلفون: Raphaela Almeida Chiareli, Gustavo Almeida Carvalho, Bruno Lemes Marques, Lennia Soares Mota, Onésia Cristina Oliveira-Lima, Rodrigo Mello Gomes, Alexander Birbrair, Renato Santiago Gomez, Fabrício Simão, Friederike Klempin, Marcel Leist, Mauro Cunha Xavier Pinto

المصدر: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

مصطلحات موضوعية: astrocytes, brain damage, neurorepair, synaptogenesis, neurogenesis, Biology (General), QH301-705.5

الوصف: Astrocytes are highly specialized glial cells responsible for trophic and metabolic support of neurons. They are associated to ionic homeostasis, the regulation of cerebral blood flow and metabolism, the modulation of synaptic activity by capturing and recycle of neurotransmitters and maintenance of the blood-brain barrier. During injuries and infections, astrocytes act in cerebral defense through heterogeneous and progressive changes in their gene expression, morphology, proliferative capacity, and function, which is known as reactive astrocytes. Thus, reactive astrocytes release several signaling molecules that modulates and contributes to the defense against injuries and infection in the central nervous system. Therefore, deciphering the complex signaling pathways of reactive astrocytes after brain damage can contribute to the neuroinflammation control and reveal new molecular targets to stimulate neurorepair process. In this review, we present the current knowledge about the role of astrocytes in brain damage and repair, highlighting the cellular and molecular bases involved in synaptogenesis and neurogenesis. In addition, we present new approaches to modulate the astrocytic activity and potentiates the neurorepair process after brain damage.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fcell.2021.665795/fullTest; https://doaj.org/toc/2296-634XTest

الوصول الحر: https://doaj.org/article/c182718b552d4de08144b415fa75b4b2Test

المؤلفون: Jolien Van houcke, Valerie Mariën, Caroline Zandecki, Eve Seuntjens, Rajagopal Ayana, Lutgarde Arckens

المصدر: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

مصطلحات موضوعية: aging, neuroregeneration strategies, neurorepair, zebrafish, killifish, medaka, Biology (General), QH301-705.5

الوصف: Aging increases the risk for neurodegenerative disease and brain trauma, both leading to irreversible and multifaceted deficits that impose a clear societal and economic burden onto the growing world population. Despite tremendous research efforts, there are still no treatments available that can fully restore brain function, which would imply neuroregeneration. In the adult mammalian brain, neuroregeneration is naturally limited, even more so in an aging context. In view of the significant influence of aging on (late-onset) neurological disease, it is a critical factor in future research. This review discusses the use of a non-standard gerontology model, the teleost brain, for studying the impact of aging on neurorepair. Teleost fish share a vertebrate physiology with mammals, including mammalian-like aging, but in contrast to mammals have a high capacity for regeneration. Moreover, access to large mutagenesis screens empowers these teleost species to fill the gap between established invertebrate and rodent models. As such, we here highlight opportunities to decode the factor age in relation to neurorepair, and we propose the use of teleost fish, and in particular killifish, to fuel new research in the neuro-gerontology field.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fcell.2021.619197/fullTest; https://doaj.org/toc/2296-634XTest

الوصول الحر: https://doaj.org/article/e6771af3c51842db9368466dcb587652Test

المؤلفون: Lennia Soares Mota, Friederike Klempin, Raphaela Almeida Chiareli, Bruno Lemes Marques, Gustavo Carvalho, Mauro Cunha Xavier Pinto, Renato Santiago Gomez, Onésia Cristina Oliveira-Lima, Rodrigo Mello Gomes, Marcel Leist, Alexander Birbrair, Fabrício Simão

المصدر: Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 9 (2021)

مصطلحات موضوعية: Cell signaling, QH301-705.5, Central nervous system, Synaptogenesis, astrocytes, brain damage, neurorepair, synaptogenesis, neurogenesis, Review, Brain damage, Biology, Cell and Developmental Biology, ddc:570, medicine, Biology (General), neurorepair, Neuroinflammation, synaptogenesis, Neurogenesis, astrocytes, brain damage, Cell Biology, medicine.disease, Astrogliosis, neurogenesis, medicine.anatomical_structure, Signal transduction, medicine.symptom, Neuroscience, Developmental Biology

الوصف: Astrocytes are highly specialized glial cells responsible for trophic and metabolic support of neurons. They are associated to ionic homeostasis, the regulation of cerebral blood flow and metabolism, the modulation of synaptic activity by capturing and recycle of neurotransmitters and maintenance of the blood-brain barrier. During injuries and infections, astrocytes act in cerebral defense through heterogeneous and progressive changes in their gene expression, morphology, proliferative capacity, and function, which is known as reactive astrocytes. Thus, reactive astrocytes release several signaling molecules that modulates and contributes to the defense against injuries and infection in the central nervous system. Therefore, deciphering the complex signaling pathways of reactive astrocytes after brain damage can contribute to the neuroinflammation control and reveal new molecular targets to stimulate neurorepair process. In this review, we present the current knowledge about the role of astrocytes in brain damage and repair, highlighting the cellular and molecular bases involved in synaptogenesis and neurogenesis. In addition, we present new approaches to modulate the astrocytic activity and potentiates the neurorepair process after brain damage.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c60d6e0a70f9a1053fe4722a0ce810fdTest
https://doi.org/10.3389/fcell.2021.665795Test

المؤلفون: Mauro Cunha Xavier Pinto, Fabrício Simão, Friederike Klempin

المصدر: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

مصطلحات موضوعية: synaptic plasticity, Angiogenesis, QH301-705.5, Neurogenesis, Cell Biology, Biology, angiogenesis, neurogenesis, Synaptic plasticity, gliogenesis, Biology (General), Neuroscience, neurorepair, Developmental Biology, Gliogenesis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd01e5bde80918c7bb25332f4f20ebb3Test
https://www.frontiersin.org/articles/10.3389/fcell.2021.740881/fullTest

المؤلفون: Friederike, Klempin, Fabricio, Simão, Mauro, Cunha Xavier Pinto

المصدر: Frontiers in Cell and Developmental Biology

مصطلحات موضوعية: Cell and Developmental Biology, angiogenesis, neurogenesis, Editorial, synaptic plasticity, gliogenesis, neurorepair

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::804572c799f66e3b63b0982da612ccc3Test
https://pubmed.ncbi.nlm.nih.gov/34458278Test