Oral Supplementation With Butyrate Improves Myocardial Ischemia/Reperfusion Injury via a Gut-Brain Neural Circuit
| العنوان: | Oral Supplementation With Butyrate Improves Myocardial Ischemia/Reperfusion Injury via a Gut-Brain Neural Circuit |
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| المؤلفون: | Zhiyao Yu, Jiapeng Han, Huaqiang Chen, Yueyi Wang, Liping Zhou, Meng Wang, Rong Zhang, Xiaoxing Jin, Guocheng Zhang, Changyi Wang, Tianyou Xu, Mengjie Xie, Xiaofei Wang, Xiaoya Zhou, Hong Jiang |
| المصدر: | Frontiers in Cardiovascular Medicine, Vol 8 (2021) Frontiers in Cardiovascular Medicine |
| بيانات النشر: | Frontiers Media S.A., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Sympathetic nervous system, medicine.medical_specialty, medicine.medical_treatment, Butyrate, Cardiovascular Medicine, chemistry.chemical_compound, Lactate dehydrogenase, Internal medicine, medicine, Diseases of the circulatory (Cardiovascular) system, Original Research, sympathetic nervous system, biology, Chemistry, gut-brain axis, Short-chain fatty acid, Sodium butyrate, Vagotomy, medicine.disease, butyrate, myocardial ischemia reperfusion injury, medicine.anatomical_structure, Endocrinology, RC666-701, biology.protein, Creatine kinase, Cardiology and Cardiovascular Medicine, short-chain fatty acid, Reperfusion injury |
| الوصف: | Objective: Butyrate, a short-chain fatty acid (SCFA) produced by the intestinal microbiota, plays a protective role in cardiovascular diseases (CVDs), but the mechanisms involved in this process remain unelucidated. We aimed to explore the effect of butyrate on myocardial ischemia/reperfusion (I/R) injury through the gut-brain neural circuit.Methods: Rats were randomly divided into four groups: sham group (sham), I/R group (I/R), I/R+ butyrate group (butyrate), and I/R+ butyrate+ vagotomy group (vagotomy). The rats were treated with sodium butyrate for 4 weeks, and the gut-brain neural circuit was investigated by subdiaphragmatic vagotomy.Results: Butyrate treatment significantly reduced the infarct size and decreased the expression of creatine kinase (CK), creatine kinase myocardial isoenzyme (CK-MB), and lactate dehydrogenase (LDH) compared with the values found for the I/R group. In addition, the I/R-induced increases in inflammation, oxidative stress, and apoptosis were attenuated by butyrate. However, the above-mentioned protective effects were diminished by subdiaphragmatic vagotomy. The RNA sequencing results also revealed that the butyrate-induced protective changes at the cardiac transcription level were reversed by vagotomy. An analysis of the heart rate variability (HRV) and the detection of norepinephrine (NE) showed that butyrate significantly inhibited the I/R-induced autonomic imbalance, but this inhibition was not observed in the vagotomy group. Butyrate treatment also suppressed the neural activity of the paraventricular nucleus (PVN) and superior cervical ganglion (SCG), and both of these effects were lost after vagotomy.Conclusions: Butyrate treatment significantly improves myocardial I/R injury via a gut-brain neural circuit, and this cardioprotective effect is likely mediated by suppression of the sympathetic nervous system. |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b0e15a01ecaa1da88bf957df33dfb09Test https://www.frontiersin.org/articles/10.3389/fcvm.2021.718674/fullTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7b0e15a01ecaa1da88bf957df33dfb09 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |