التفاصيل البيبلوغرافية
| العنوان: |
Independent effect of body mass index variation on amyloid-β positivity |
| المؤلفون: |
Kang, Sung Hoon, Kim, Jong Hyuk, Chang, Yoosoo, Cheon, Bo Kyoung, Choe, Yeong Sim, Jang, Hyemin, Kim, Hee Jin, Koh, Seong-Beom, Na, Duk L., Kim, Kyunga, Seo, Sang Won |
| المساهمون: |
Korea Health Industry Development Institute, Korea Centers for Disease Control and Prevention, Ministry of Health and Welfare |
| المصدر: |
Frontiers in Aging Neuroscience ; volume 14 ; ISSN 1663-4365 |
| بيانات النشر: |
Frontiers Media SA |
| سنة النشر: |
2022 |
| المجموعة: |
Frontiers (Publisher - via CrossRef) |
| مصطلحات موضوعية: |
Cognitive Neuroscience, Aging |
| الوصف: |
Objectives The relationship of body mass index (BMI) changes and variability with amyloid-β (Aβ) deposition remained unclear, although there were growing evidence that BMI is associated with the risk of developing cognitive impairment or AD dementia. To determine whether BMI changes and BMI variability affected Aβ positivity, we investigated the association of BMI changes and BMI variability with Aβ positivity, as assessed by PET in a non-demented population. Methods We retrospectively recruited 1,035 non-demented participants ≥50 years of age who underwent Aβ PET and had at least three BMI measurements in the memory clinic at Samsung Medical Center. To investigate the association between BMI change and variability with Aβ deposition, we performed multivariable logistic regression. Further distinctive underlying features of BMI subgroups were examined by employing a cluster analysis model. Results Decreased (odds ratio [OR] = 1.68, 95% confidence interval [CI] 1.16–2.42) or increased BMI (OR = 1.60, 95% CI 1.11–2.32) was associated with a greater risk of Aβ positivity after controlling for age, sex, APOE e4 genotype, years of education, hypertension, diabetes, baseline BMI, and BMI variability. A greater BMI variability (OR = 1.73, 95% CI 1.07–2.80) was associated with a greater risk of Aβ positivity after controlling for age, sex, APOE e4 genotype, years of education, hypertension, diabetes, baseline BMI, and BMI change. We also identified BMI subgroups showing a greater risk of Aβ positivity. Conclusion Our findings suggest that participants with BMI change, especially those with greater BMI variability, are more vulnerable to Aβ deposition regardless of baseline BMI. Furthermore, our results may contribute to the design of strategies to prevent Aβ deposition with respect to weight control. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| DOI: |
10.3389/fnagi.2022.924550 |
| DOI: |
10.3389/fnagi.2022.924550/full |
| الإتاحة: |
https://doi.org/10.3389/fnagi.2022.924550Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.79DFF53A |
| قاعدة البيانات: |
BASE |
