التفاصيل البيبلوغرافية
| العنوان: |
Neuroinflammation and neurodegeneration in diabetic retinopathy. |
| المؤلفون: |
Bianco, Lorenzo, Arrigo, Alessandro, Aragona, Emanuela, Antropoli, Alessio, Berni, Alessandro, Saladino, Andrea, Parodi, Maurizio Battaglia, Bandello, Francesco |
| المصدر: |
Frontiers in Aging Neuroscience; 8/16/2022, Vol. 14, p1-17, 17p |
| مصطلحات موضوعية: |
DIABETES complications, RISK factors of neurodegeneration, THERAPEUTIC use of vitamin B12, BIOMARKERS, CYTOKINES, ADRENOCORTICAL hormones, ANTI-inflammatory agents, NONSTEROIDAL anti-inflammatory agents, DIAGNOSTIC imaging, NUCLEOTIDES, CAROTENOIDS, CELL adhesion molecules, NEUROPROTECTIVE agents, LIPOIC acid, DIABETIC retinopathy, CHEMOKINES, NEURITIS, NEURODEGENERATION, PEPTIDES, DISEASE risk factors |
| مستخلص: |
Diabetic retinopathy (DR) is the most common complication of diabetes and has been historically regarded as a microangiopathic disease. Now, the paradigm is shifting toward a more comprehensive view of diabetic retinal disease (DRD) as a tissue-specific neurovascular complication, in which persistently high glycemia causes not only microvascular damage and ischemia but also intraretinal inflammation and neuronal degeneration. Despite the increasing knowledge on the pathogenic pathways involved in DR, currently approved treatments are focused only on its latestage vasculopathic complications, and a single molecular target, vascular endothelial growth factor (VEGF), has been extensively studied, leading to drug development and approval. In this review, we discuss the state of the art of research on neuroinflammation and neurodegeneration in diabetes, with a focus on pathophysiological studies on human subjects, in vivo imaging biomarkers, and clinical trials on novel therapeutic options. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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