التفاصيل البيبلوغرافية
| العنوان: |
The antioxidant activity and neuroprotective mechanism of isoliquiritigenin. |
| المؤلفون: |
Shi, Dingding1,2 (AUTHOR), Yang, Jiali1,2 (AUTHOR), Jiang, Yueming1,2,3 (AUTHOR), Wen, Lingrong1,2,3 (AUTHOR) wenlingrong@scbg.ac.cn, Wang, Zhubin4 (AUTHOR), Yang, Bao1,2,3 (AUTHOR) yangbao@scbg.ac.cn |
| المصدر: |
Free Radical Biology & Medicine. May2020, Vol. 152, p207-215. 9p. |
| مصطلحات موضوعية: |
*LACTATE dehydrogenase, *SUPEROXIDE dismutase, *MEMBRANE potential, *GLUTATHIONE peroxidase, *MITOCHONDRIAL membranes, *APOPTOSIS |
| مصطلحات جغرافية: |
ASIA |
| مستخلص: |
Glycyrrhizae radix has been widely accepted as a functional food in Asia. Isoliquiritigenin is a characteristic bioactive chemical in this medicinal plant. In this work, the neuroprotective effect of isoliquiritigenin and the possible mechanisms were investigated. The results revealed that isoliquiritigenin exhibited better neuroprotective and antioxidant activities than quercetin, a commercial natural antioxidant. Isoliquiritigenin significantly inhibited the release of lactate dehydrogenase, and the generation of reactive oxygen species in H 2 O 2 -treated cells. The activities of superoxide dismutase, glutathione peroxidase and catalase were improved. The mRNA expression levels related to oxidative defense and cell apoptosis were reversed by isoliquiritigenin. Moreover, isoliquiritigenin might inhibit the cell apoptosis via ameliorating the loss of mitochondrial membrane potential and the change of nucleus morphology. Image 1 • Isoliquiritigenin has a good neuroprotective activity. • Isoliquiritigenin can regulate the antioxidant system. • Isoliquiritigenin inhibits the cell apoptosis. • The neuroprotective mechanism of isoliquiritigenin is revealed. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
