Paeoniflorin attenuates gestational diabetes via Akt/mTOR pathway in a rat model
| العنوان: | Paeoniflorin attenuates gestational diabetes via Akt/mTOR pathway in a rat model |
|---|---|
| المؤلفون: | Bo Chen, Ying Huang, Yonghua Zhang, Yulin Liang, Huiqiao Liu, Hongmei Li |
| المصدر: | Food & Nutrition Research, Vol 64, Iss 0, Pp 1-9 (2020) Food & Nutrition Research |
| بيانات النشر: | Swedish Nutrition Foundation, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, insulin, endocrine system diseases, medicine.medical_treatment, 030209 endocrinology & metabolism, lcsh:TX341-641, 03 medical and health sciences, chemistry.chemical_compound, paeoniflorin, 0302 clinical medicine, Diabetes mellitus, Internal medicine, mtor, Medicine, glucose, Protein kinase B, PI3K/AKT/mTOR pathway, 030109 nutrition & dietetics, Nutrition and Dietetics, gdm, business.industry, Leptin, Insulin, Public Health, Environmental and Occupational Health, nutritional and metabolic diseases, medicine.disease, Paeoniflorin, Streptozotocin, Gestational diabetes, Endocrinology, chemistry, Original Article, business, lcsh:Nutrition. Foods and food supply, Food Science, medicine.drug |
| الوصف: | Background Gestational diabetes mellitus (GDM) is a type of diabetes associated with pregnancy and may impose risks on both mother and fetus. Akt paeoniflorin was shown to have anti-inflammatory and anti-hyperglycemia properties and has a potential ability to suppress mammalian target of rapamycin (mTOR) signaling. The current study aimed to study the effect of paeoniflorin on GDM maternal, fetal, and placental characteristics in vivo. Methods Streptozotocin (STZ)-induced gestational diabetes rat model was used in our study. The expression levels of phosphorylation (p-) and total protein expression levels of protein kinase B (Akt), mTOR, serum/glucocorticoid regulated kinase 1 (SGK1), and eIF4E-binding protein 1 (4E-BP1) in the placenta were determined by Western blot assay. The blood glucose, insulin, and leptin levels were assessed using enzyme-linked immunosorbent assay (ELISA). Results We found that placental Akt/mTOR signaling was substantially upregulated in GDM patients compared with healthy donors. Paeoniflorin administration alleviates the dysregulation of blood glucose, leptin, and insulin levels in both maternal and fetal GDM rats. Paeoniflorin treatment suppressed the overactivation of Akt/mTOR signaling in placental tissues. More importantly, administration of paeoniflorin was beneficial for normalization of fetal size and body weight in the GDM rats. Conclusion Our study suggested that application of paeoniflorin may serve as a potential therapeutical strategy for patients with GDM. |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::becd7aa80c726b987da4b23403dd79b8Test https://foodandnutritionresearch.net/index.php/fnr/article/view/4362/11263Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....becd7aa80c726b987da4b23403dd79b8 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |