Pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin in Pacific white shrimp Litopenaeus vannamei after multiple-dose oral administration
| العنوان: | Pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin in Pacific white shrimp Litopenaeus vannamei after multiple-dose oral administration |
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| المؤلفون: | Xiong Zou, Wenhong Fang, Wenjuan Wei, Junfang Zhou, Yuan Wang, Liang Huang, Xin-Cang Li, Rongrong Ma |
| المصدر: | Fisheries Science. 84:869-876 |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, animal structures, biology, Chemistry, animal diseases, fungi, Cmax, 04 agricultural and veterinary sciences, biochemical phenomena, metabolism, and nutrition, Aquatic Science, Pharmacology, biology.organism_classification, Shrimp, 03 medical and health sciences, 030104 developmental biology, Pharmacokinetics, Oral administration, Pharmacodynamics, Hemolymph, 040102 fisheries, Enrofloxacin, medicine, 0401 agriculture, forestry, and fisheries, Hepatopancreas, medicine.drug |
| الوصف: | The present study was designed to explore pharmacokinetics (PK) of enrofloxacin and its metabolite ciprofloxacin in Pacific white shrimp Litopenaeus vannamei after multiple-dose oral administration of enrofloxacin (30 mg/kg dose per 12 h and continuous feeding for 3 days). Enrofloxacin and ciprofloxacin concentrations in hemolymph, hepatopancreas, and muscle of the shrimp were simultaneously determined by high-performance liquid chromatography. PK parameters were analyzed based on statistical moment theory. Meanwhile, the relationship of pharmacokinetics/pharmacodynamics (PK/PD) was established based on drug concentration of hemolymph and in vitro antibacterial activity (MIC value). Results showed faster absorption of enrofloxacin in hemolymph (Tmax = 1 h) and muscles (Tmax = 1 h) than that in hepatopancreas (Tmax = 3 h) after the first oral administration. In multiple-dose oral administration, slight accumulation of enrofloxacin occurred in the hemolymph and hepatopancreas, while in the muscle, enrofloxacin concentration showed a significant decline following multiple administration. Tissue distribution of enrofloxacin and ciprofloxacin both followed the order hepatopancreas > hemolymph > muscle, with significantly higher ciprofloxacin concentration in hepatopancreas than in hemolymph (approximately 10-fold) and muscles (approximately 50-fold), indicating that the hepatopancreas is the main organ involved in metabolism of enrofloxacin in Pacific white shrimp. After multiple-dose administration, Cmax/MIC and AUC0–24/MIC values showed that the therapeutic regimen in this study could be remarkably effective in prevention and treatment of Vibrio infection in Pacific white shrimp. |
| تدمد: | 1444-2906 0919-9268 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::2b1e76ea348db0572cd811eb67fa99a2Test https://doi.org/10.1007/s12562-018-1229-yTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........2b1e76ea348db0572cd811eb67fa99a2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14442906 09199268 |
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