المؤلفون: Dracopoulos, Christoph¹ (AUTHOR), Gembicki, Michael¹ (AUTHOR), Scharf, Jann Lennard¹ (AUTHOR), Welp, Amrei¹ (AUTHOR), Berg, Nadine² (AUTHOR), Weichert, Jan¹ (AUTHOR)

المصدر: Fetal & Pediatric Pathology. Oct2022, Vol. 41 Issue 5, p871-880. 10p.

مصطلحات موضوعية: *NEURAL tube defects, *HYDROCEPHALUS, *MULLERIAN ducts, *FETUS, *CERVICAL vertebrae

مستخلص: Congenital multisystemic lesions with co-occurrence of non-random malformations, such as VACTERL-H or MURCS association, often pose serious threads to the newborn and still constitute an antenatal diagnostic dilemma. A malformed fetus with VACTERL-H association at 20 gestational weeks had a skin-covered neural tube defect (NTD) of the lower cervical spine, concomitant hydrocephalus, as well as unilateral multicystic dysplastic kidney and the suspicion of mullerian duct anomaly as potentially assigned to MURCS association. We were able to demonstrate how well-defined, standardized volumetric reconstruction of diagnostic views displaying fetal pathology in utero might aid early and precise diagnosis of multi-organ malformations. Application of modern diagnostic imaging tools is helpful in delineation of the most likely diagnoses (VACTERL-H vs. MURCS) as further specified during detailed pathologic work-up and might consequently facilitate individually tailored interdisciplinary counseling, as in the case presented here. [ABSTRACT FROM AUTHOR]

المؤلفون: Nariai, Hiroki, Price, Dana E., Jada, Ajit, Weintraub, Lauren, Weidenheim, Karen M., Gomes, William A., Levy, Adam S., Abbott, Rick, Malbari, Fatema

المصدر: Fetal & Pediatric Pathology; Aug2016, Vol. 35 Issue 4, p260-264, 5p

مصطلحات موضوعية: INTRACRANIAL pressure, TERATOMA, HYDROCEPHALUS, VENTRICULAR aneurysms, CELL proliferation

مستخلص: Objective:To describe clinicopathological correlation of congenital intracranial immature teratoma.Methods:A retrospective case analysis from a tertiary medical center.Results:We report a case of an intracranial immature teratoma detected prenatally at 35 weeks of gestation. The tumor showed rapid growth, causing acute hydrocephalus requiring subsequent ventriculoperitoneal shunting. Resective surgery was performed within 2 weeks after birth. The infant died at day of life 29. Histological examination revealed an immature teratoma, with high MIB1/Ki-67 proliferation index.Conclusion/Implications:Intracranial immature teratoma with high MIB1/Ki-67 proliferation index may serve as an independent poor prognostic factor. [ABSTRACT FROM PUBLISHER]

: Copyright of Fetal & Pediatric Pathology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Kariminejad, Ariana, Ghaderi-Sohi, Siavash, Kariminejad, Mohammad Hassan, Lachman, Ralph

المصدر: Fetal & Pediatric Pathology; Oct2012, Vol. 31 Issue 5, p295-299, 5p, 1 Color Photograph, 1 Black and White Photograph, 1 Diagram

مصطلحات موضوعية: CONJUNCTIVA diseases, CLEFT lip, HYDROCEPHALUS, CIRRHOSIS of the liver, CLEFT palate, CILIARY body diseases, KARYOTYPES

مستخلص: We report on a male infant born at 38 weeks of gestation with hydrocephalus, right anophthalmia, left microphthalmia, cleft palate, midline cleft of lip, and microphallus. Autopsy showed pulmonary bronchial lymphangiectasia, hepatic periportal fibrosis, adrenal agenesis, ventricular septal defect, aortic stenosis, and undescended testes. The radiographic findings include short limbs and mild shortness of ribs. Karyotype with high-resolution banding was normal (46,XY). The combination of anomalies in this case could suggest a ciliopathy and may represent a new entity similar to that described by Cideciyan et al. [1]. [ABSTRACT FROM AUTHOR]

: Copyright of Fetal & Pediatric Pathology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Lach, Boleslaw, Haust, Maria D.

المصدر: Fetal & Pediatric Pathology; Jun2011, Vol. 30 Issue 3, p189-198, 10p, 7 Black and White Photographs

مصطلحات موضوعية: NEUROLOGICAL disorders, CHOROID plexus, GLOMUS (Fungi), FIBROBLASTS, HYDROCEPHALUS

مستخلص: Neuropathologic examination of six brains from children with Hurler disease revealed nodular lesions in the glomus of choroid plexus caused by proliferation of vacuolated pericytes, fibroblasts, and arachnoid cells on the background of collagenized and myxoid stroma. This localization of lesions can be explained by the presence of a rich vascular network, as well as cellular heterogeneity greater in the glomus than in other parts of the choroid plexus or in the brain parenchyma. The development of nodules did not correlate with the age, severity of hydrocephalus, or the degree of expansion of the perivascular spaces in the brain. [ABSTRACT FROM AUTHOR]

: Copyright of Fetal & Pediatric Pathology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Bare, Jessica B., Abramowsky, Carlos R., Hayes, Laura L., Shehata, Bahig M.

المصدر: Fetal & Pediatric Pathology; May/Jun2007, Vol. 26 Issue 3, p109-118, 10p, 5 Black and White Photographs

مصطلحات موضوعية: TERATOMA, AUTOPSY, PREGNANCY, CESAREAN section, FETUS, HYDROCEPHALUS, TUMORS

مستخلص: Three cases of congenital immature intracranial teratomas were examined by autopsy. The fetuses were diagnosed prenatally as macrocephalic and hydrocephalic due to skull-occupying lesions. These fetuses were born alive at 32, 31, and 36 weeks gestation, respectively, via Cesarean section. Intracranial teratoma in the first case was diagnosed by MRI and in the second and third cases by ultrasound. All tumors were deemed to be unresectable. Congenital CNS teratoma should be considered in the differential diagnosis of fetuses diagnosed with macrocephaly or hydrocephaly. [ABSTRACT FROM AUTHOR]

: Copyright of Fetal & Pediatric Pathology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)