التفاصيل البيبلوغرافية
العنوان:
Evidence of a genetic link between endometriosis and ovarian cancer
المؤلفون:
Alice W. Lee , Claire Templeman , Douglas A. Stram , Jonathan Beesley , Jonathan Tyrer , Andrew Berchuck , Paul P. Pharoah , Georgia Chenevix-Trench , Celeste Leigh Pearce , Roberta B. Ness , Agnieszka Dansonka-Mieszkowska , Aleksandra Gentry-Maharaj , Alexander Hein , Alice S. Whittemore , Allan Jensen , Andreas du Bois , Angela Brooks-Wilson , Anja Rudolph , Anna Jakubowska , Anna H. Wu , Argyrios Ziogas , Arif B. Ekici , Arto Leminen , Barry Rosen , Beata Spiewankiewicz , Beth Y. Karlan , Britton Trabert , Brooke L. Fridley , C. Blake Gilks , Camilla Krakstad , Catherine M. Phelan , Cezary Cybulski , Christine Walsh , Claus Hogdall , Daniel W. Cramer , David G. Huntsman , Diana Eccles , Diether Lambrechts , Dong Liang , Douglas A. Levine , Edwin S. Iversen , Elisa V. Bandera , Elizabeth M. Poole , Ellen L. Goode , Els Van Nieuwenhuysen , Estrid Hogdall , Fiona Bruinsma , Florian Heitz , Francesmary Modugno , Graham G. Giles , Harvey A. Risch , Helen Baker , Helga B. Salvesen , Heli Nevanlinna , Hoda Anton-Culver , Honglin Song , Iain McNeish , Ian G. Campbell , Ignace Vergote , Ingo B. Runnebaum , Ingvild L. Tangen , Ira Schwaab , Jacek Gronwald , James Paul , Jan Lubinski , Jennifer A. Doherty , Jenny Chang-Claude , Jenny Lester , Joellen M. Schildkraut , John R. McLaughlin , Jolanta Lissowska , Jolanta Kupryjanczyk , Joseph L. Kelley , Joseph H. Rothstein , Julie M. Cunningham , Karen Lu , Karen Carty , Kathryn L. Terry , Katja K.H. Aben , Kirsten B. Moysich , Kristine G. Wicklund , Kunle Odunsi , Lambertus A. Kiemeney , Lara Sucheston-Campbell , Lene Lundvall , Leon F.A.G. Massuger , Liisa M. Pelttari , Linda E. Kelemen , Linda S. Cook , Line Bjorge , Lotte Nedergaard , Louise A. Brinton , Lynne R. Wilkens , Malcolm C. Pike , Marc T. Goodman , Maria Bisogna , Mary Anne Rossing , Matthias W. Beckmann , Matthias Dürst , Melissa C. Southey , Melissa Kellar , Michelle A.T. Hildebrandt , Nadeem Siddiqui , Natalia Antonenkova , Natalia Bogdanova , Nhu D. Le , Nicolas Wentzensen , Pamela J. Thompson , Patricia Harrington , Penelope M. Webb , Peter A. Fasching , Peter Hillemanns , Philipp Harter , Piotr Sobiczewski , Rachel Palmieri Weber , Ralf Butzow , Robert P. Edwards , Robert A. Vierkant , Rosalind Glasspool , Sandra Orsulic , Sandrina Lambrechts , Sara H. Olson , Shan Wang-Gohrke , Shashi Lele , Shelley S. Tworoger , Simon A. Gayther , Stacey A. Missmer , Steven A. Narod , Susan J. Ramus , Susanne K. Kjaer , Tanja Pejovic , Thilo Dörk , Ursula Eilber , Usha Menon , Valerie McGuire , Weiva Sieh , Xifeng Wu , Yukie Bean , Yurii B. Shvetsov
المصدر:
Fertility and Sterility, 105, 1, pp. 35-43.e10
سنة النشر:
2016
مصطلحات موضوعية:
0301 basic medicine , Oncology , medicine.medical_specialty , endocrine system diseases , Endometriosis , Genome-wide association study , Single-nucleotide polymorphism , Disease , Biology , Polymorphism, Single Nucleotide , Risk Assessment , Article , 03 medical and health sciences , Risk Factors , Internal medicine , Databases, Genetic , Genetic variation , medicine , Humans , Genetic Predisposition to Disease , Genetic testing , Ovarian Neoplasms , Gynecology , Women's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17] , medicine.diagnostic_test , Case-control study , Computational Biology , Obstetrics and Gynecology , medicine.disease , female genital diseases and pregnancy complications , Women's cancers Radboud Institute for Health Sciences [Radboudumc 17] , Phenotype , 030104 developmental biology , Reproductive Medicine , Case-Control Studies , Urological cancers Radboud Institute for Health Sciences [Radboudumc 15] , Female , Neoplasm Grading , Ovarian cancer , Genome-Wide Association Study
الوصف:
Contains fulltext : 172500.pdf (Publisher’s version ) (Closed access) OBJECTIVE: To evaluate whether endometriosis-associated genetic variation affects risk of ovarian cancer. DESIGN: Pooled genetic analysis. SETTING: University hospital. PATIENT(S): Genetic data from 46,176 participants (15,361 ovarian cancer cases and 30,815 controls) from 41 ovarian cancer studies. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Endometriosis-associated genetic variation and ovarian cancer. RESULT(S): There was significant evidence of an association between endometriosis-related genetic variation and ovarian cancer risk, especially for the high-grade serous and clear cell histotypes. Overall we observed 15 significant burden statistics, which was three times more than expected. CONCLUSION(S): By focusing on candidate regions from a phenotype associated with ovarian cancer, we have shown a clear genetic link between endometriosis and ovarian cancer that warrants further follow-up. The functional significance of the identified regions and SNPs is presently uncertain, though future fine mapping and histotype-specific functional analyses may shed light on the etiologies of both gynecologic conditions.
وصف الملف:
application/pdf
تدمد:
0015-0282
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e856617f27e3f4716b09f524c8f53d6dTest https://hdl.handle.net/2066/172500Test
حقوق:
OPEN
رقم الانضمام:
edsair.doi.dedup.....e856617f27e3f4716b09f524c8f53d6d
قاعدة البيانات:
OpenAIRE
