Identification of a truncated kinase suppressor of Ras 2 mRNA in sperm
| العنوان: | Identification of a truncated kinase suppressor of Ras 2 mRNA in sperm |
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| المؤلفون: | Lili Guo, Deanna J. Volle, Robert E. Lewis |
| المصدر: | FEBS Open Bio, Vol 4, Iss C, Pp 420-425 (2014) FEBS Open Bio |
| بيانات النشر: | Wiley, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | MAPK/ERK pathway, Scaffold protein, KSR, kinase suppressor of Ras, NDK-1, nucleoside diphosphate kinase 1, Article, General Biochemistry, Genetics and Molecular Biology, Germline, Scaffold, 03 medical and health sciences, 0302 clinical medicine, Protein kinase A, lcsh:QH301-705.5, T-KSR2, testes-kinase suppressor of Ras 2, Caenorhabditis elegans, 030304 developmental biology, 0303 health sciences, biology, KSR2, Kinase, CA, conserved area, biology.organism_classification, Molecular biology, Sperm, 3. Good health, ERK, extracellular signal-regulated protein kinase, lcsh:Biology (General), Mitogen-activated protein kinase, biology.protein, RACE, rapid amplification of cDNA ends, Signal transduction, SH2, Src homology 2, 030217 neurology & neurosurgery, MAPK, mitogen activated protein kinase |
| الوصف: | Highlights • A truncated kinase suppressor of Ras 2 (T-KSR2) mRNA was identified. • T-KSR2 is expressed exclusively in mouse testes and sperm. • Analysis of T-KSR2 may enhance understanding of spermatogenesis and fertility. The kinase suppressor of Ras 2 (KSR2) is a scaffold protein for the extracellular signal-regulated protein kinase (ERK) signaling pathway. KSR2 mediates germline mpk-1 (Caenorhabditis elegans ERK) phosphorylation in C. elegans and has been implicated the regulation of meiosis. KSR2−/− mice exhibit metabolic abnormalities and are reproductively impaired. The role of KSR2 in meiosis and fertility in mice has yet to be elucidated. Here, we describe a novel truncated KSR2 mRNA identified in mouse testes (T-KSR2). Further analysis demonstrates T-KSR2 is specific to mouse testes and mature sperm cells. The detection of T-KSR2 may enhance our understanding of mechanisms controlling spermatogenesis and fertility. |
| تدمد: | 2211-5463 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b6ced0b95425d61d2246924e590891Test https://doi.org/10.1016/j.fob.2014.04.004Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e4b6ced0b95425d61d2246924e590891 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22115463 |
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