Knockdown of RNF6 inhibits HeLa cervical cancer cell growth via suppression of MAPK/ERK signaling
| العنوان: | Knockdown of RNF6 inhibits HeLa cervical cancer cell growth via suppression of MAPK/ERK signaling |
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| المؤلفون: | Kang Zhu, Zhao Duan, He Bai, Yuanyuan Xue, Mingzhu Mu |
| المصدر: | FEBS Open Bio, Vol 11, Iss 7, Pp 2041-2049 (2021) FEBS Open Bio |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, MAPK/ERK pathway, cervical cancer, QH301-705.5, Uterine Cervical Neoplasms, Cervix Uteri, RNF6, General Biochemistry, Genetics and Molecular Biology, HeLa, 03 medical and health sciences, 0302 clinical medicine, Cervical carcinoma, medicine, Humans, cell growth, Biology (General), Adverse effect, Research Articles, Cell Proliferation, Cervical cancer, Gene knockdown, biology, Cell growth, business.industry, medicine.disease, biology.organism_classification, DNA-Binding Proteins, ERK, 030104 developmental biology, Apoptosis, 030220 oncology & carcinogenesis, Cancer research, Female, business, Research Article, HeLa Cells |
| الوصف: | Ring finger protein 6 (RNF6) is implicated in various human malignancies, but its function in cervical cancer (CC) is incompletely understood. Here, we explored the biological significance of RNF6 in HeLa CC cells and the underlying regulatory mechanisms. The expression of RNF6 was observed to be high in both primary tissues and CC cells. RNF6 promoted HeLa CC cell growth. Knockdown of RNF6 in CC cells resulted in suppression of proliferation and promotion of apoptosis. Moreover, elevation of RNF6 had an adverse effect on the prognosis of CC. Subsequent analyses showed that these effects may be mediated via activation of ERK signaling. These findings provide evidence that the knockdown of RNF6 suppresses the MAPK/ERK pathway to regulate the growth of CC cells, which suggests that RNF6 may have potential as a target for diagnosis and treatment for CC. We confirmed that ring finger protein 6 (RNF6) expression was significantly increased in cervical cancer (CC) tissues and HeLa cells, and this was associated with poor prognosis of CC patients. Knockdown of RNF6 inhibited cell proliferation and promoted apoptosis by suppression of the MAPK/ERK signaling pathway in HeLa cells. Consequently, targeting the RNF6‐ERK pathway may have potential for the development of treatments for CC. |
| اللغة: | English |
| تدمد: | 2211-5463 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f9701a2af592af19881e5863d32e47cTest https://doaj.org/article/479c28ed82ce4a0f957f13bf015e326fTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2f9701a2af592af19881e5863d32e47c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22115463 |
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