التفاصيل البيبلوغرافية
| العنوان: |
The chromatin modifier MORC2 affects glucose metabolism by regulating the expression of lactate dehydrogenase A through a feed forward loop with c‐Myc. |
| المؤلفون: |
Guddeti, Rohith Kumar, Thomas, Liz, Kannan, Anbarasu, Karyala, Prashanthi, Pakala, Suresh B., Nebreda, Angel |
| المصدر: |
FEBS Letters; May2021, Vol. 595 Issue 9, p1289-1302, 14p |
| مصطلحات موضوعية: |
GLUCOSE metabolism, LACTATE dehydrogenase, ZINC-finger proteins, CANCER cell migration, CHROMATIN, ENZYME metabolism, GENE targeting |
| مستخلص: |
Microrchidia family CW‐type zinc finger 2 (MORC2) is a recently identified chromatin modifier with an emerging role in cancer metastasis. However, its role in glucose metabolism, a hallmark of malignancy, remains to be explored. We found that MORC2 is a glucose‐inducible gene and a target of c‐Myc. Our meta‐analysis revealed that MORC2 expression is positively correlated with the expression of enzymes involved in glucose metabolism in breast cancer patients. Furthermore, overexpression of MORC2 in MCF‐7 and BT‐549 cells augmented the expression and activity of a key glucose metabolism enzyme, lactate dehydrogenase A (LDHA). Conversely, selective knockdown of MORC2 by siRNA markedly decreased LDHA expression and activity and in turn reduced cancer cell migration. Collectively, these findings provide evidence that MORC2, a glucose‐inducible gene, modulates the migration of breast cancer cells through the MORC2–c‐Myc–LDHA axis. [ABSTRACT FROM AUTHOR] |
|
Copyright of FEBS Letters is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder