التفاصيل البيبلوغرافية
| العنوان: |
c-Abl and Src-family kinases cross-talk in regulation of myeloid cell migration |
| المؤلفون: |
Baruzzi, Anna, Iacobucci, Ilaria, Soverini, Simona, Lowell, Clifford A., Martinelli, Giovanni, Berton, Giorgio |
| المصدر: |
FEBS Letters; Jan2010, Vol. 584 Issue 1, p15-21, 7p |
| مصطلحات موضوعية: |
PROTEIN-tyrosine kinases, CELL migration, PHOSPHORYLATION, CYTOSKELETON, MACROPHAGES, NEUTROPHILS, CELLULAR signal transduction, CHEMOTAXIS |
| مستخلص: |
Abstract: Cytoskeleton dynamics are regulated by Src-family tyrosine kinases (SFKs) and c-Abl. We found that the SFK members Hck and c-Fgr regulate tyrosine phosphorylation of c-Abl and c-Abl associates with β1 integrin-bound Hck or c-Fgr in murine macrophages. Studies with selective inhibitors and cells from SFK-deficient mice showed that c-Abl and SFK regulate migration and activation of the small GTPases Cdc42 and Rac in macrophages. Additionally, human neutrophil chemotactic activity was reduced by c-Abl inhibitors, and neutrophils from chronic myeloid leukaemia patients displayed an increased chemotactic ability. Hence, Src-family kinase and c-Abl cross-talk in the regulation of myeloid cell migration. Structured summary: MINT-7296608: Integrin beta-1 (uniprotkb:P09055) physically interacts (MI:0914) with Hck (uniprotkb:P08103), Abl (uniprotkb:P00520) and Fgr (uniprotkb:P14234) by anti bait coimmunoprecipitation (MI:0006) MINT-7296596: Integrin beta-1 (uniprotkb:P09055) physically interacts (MI:0914) with Fgr (uniprotkb:P14234) and Abl (uniprotkb:P00520) by anti bait coimmunoprecipitation (MI:0006) [Copyright &y& Elsevier] |
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| قاعدة البيانات: |
Complementary Index |
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