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Adding structural information to the von Hippel–Lindau (VHL) tumor suppressor interaction network

التفاصيل البيبلوغرافية
العنوان: Adding structural information to the von Hippel–Lindau (VHL) tumor suppressor interaction network
المؤلفون: Alessandra Murgia, Emanuela Leonardi, Silvio C. E. Tosatto
المصدر: FEBS Letters. (22):3704-3710
بيانات النشر: Federation of European Biochemical Societies. Published by Elsevier B.V.
مصطلحات موضوعية: Models, Molecular, Tumor suppressor gene, Molecular Sequence Data, Biophysics, Bioengineering, Computational biology, Biology, urologic and male genital diseases, Biochemistry, Linear motif, law.invention, Protein–protein interaction, Hypoxia inducible factor, Structural bioinformatics, Structural Biology, law, Interaction network, Genetics, Animals, Humans, Amino Acid Sequence, Databases, Protein, Molecular Biology, Gene, Binding Sites, Sequence Homology, Amino Acid, Chemistry, Protein interaction, Computational Biology, Cell Biology, General Medicine, Subcellular localization, female genital diseases and pregnancy complications, Cell biology, Protein Structure, Tertiary, Von Hippel–Lindau, Hypoxia-inducible factors, Tumor progression, Von Hippel-Lindau Tumor Suppressor Protein, Von Hippel–Lindau, Hypoxia inducible factor, Structural bioinformatics, Linear motif, Protein interaction, Suppressor, Carrier Proteins, Function (biology), Biotechnology, Protein Binding
الوصف: The von Hippel–Lindau (VHL) tumor suppressor gene is a protein interaction hub, controlling numerous genes implicated in tumor progression. Here we focus on structural aspects of protein interactions for a list of 35 experimentally verified protein VHL (pVHL) interactors. Using structural information and computational analysis we have located three distinct interaction interfaces (A, B, and C). Interface B is the most versatile, recognizing a refined linear motif present in 17 otherwise non-related proteins. It has been possible to distinguish compatible and exclusive interactions by relating pVHL function to interaction interfaces and subcellular localization. A novel hypothesis is presented regarding the possible function of the N-terminus as an inhibitor of pVHL function.
اللغة: English
تدمد: 0014-5793
DOI: 10.1016/j.febslet.2009.10.070
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8475a05b09c195d58eb99e79ebee650bTest
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....8475a05b09c195d58eb99e79ebee650b
قاعدة البيانات: OpenAIRE
الوصف
تدمد:00145793
DOI:10.1016/j.febslet.2009.10.070