التفاصيل البيبلوغرافية
| العنوان: |
Anethole induces apoptotic cell death accompanied by reactive oxygen species production and DNA fragmentation in Aspergillus fumigatus and Saccharomyces cerevisiae. |
| المؤلفون: |
Fujita, Ken‐Ichi1, Tatsumi, Miki1, Ogita, Akira1,2, Kubo, Isao3, Tanaka, Toshio1 |
| المصدر: |
FEBS Journal. Feb2014, Vol. 281 Issue 4, p1304-1313. 10p. |
| مصطلحات موضوعية: |
*CELL death, *REACTIVE oxygen species, *FRAGMENTATION reactions, *ASPERGILLUS fumigatus, *SACCHAROMYCES cerevisiae, *ANTI-infective agents, *POLYGODIAL, *PATHOGENIC fungi |
| مستخلص: |
trans-Anethole (anethole), a major component of anise oil, has a broad antimicrobial spectrum, and antimicrobial activity that is weaker than that of other antibiotics on the market. When combined with polygodial, nagilactone E, and n-dodecanol, anethole has been shown to possess significant synergistic antifungal activity against a budding yeast, Saccharomyces cerevisiae, and a human opportunistic pathogenic yeast, Candida albicans. However, the antifungal mechanism of anethole has not been completely determined. We found that anethole stimulated cell death of a human opportunistic pathogenic fungus, Aspergillus fumigatus, in addition to S. cerevisiae. The anethole-induced cell death was accompanied by reactive oxygen species production, metacaspase activation, and DNA fragmentation. Several mutants of S. cerevisiae, in which genes related to the apoptosis-initiating execution signals from mitochondria were deleted, were resistant to anethole. These results suggest that anethole-induced cell death could be explained by oxidative stress-dependent apoptosis via typical mitochondrial death cascades in fungi, including A. fumigatus and S. cerevisiae. [ABSTRACT FROM AUTHOR] |
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