التفاصيل البيبلوغرافية
| العنوان: |
Repression of lipin-1 in mouse adipose tissue and 3T3-L1 adipocytes by LPS and proinflammatory cytokines. |
| المؤلفون: |
Biao Lu, Yang Lu, Moser, Arthur H., Shigenaga, Judy K., Grunfeld, Carl, Feingold, Kenneth R. |
| المصدر: |
FASEB Journal; Apr2007, Vol. 21 Issue 5, pA704-A704, 1/6p |
| مصطلحات موضوعية: |
LIPIDS, ADIPOSE tissues, FAT cells, MICE, POLYSACCHARIDES, CHEMOKINES |
| مستخلص: |
Infection and inflammation affect adipose energy homeostasis and triglyceride (TG) metabolism, which contributes to dyslipidemia during the acute-phase response (APR). Lipin-1, a multifunctional protein, plays a critical role in adipose differentiation, mitochondrial oxidation, and TG synthesis. Here, we examined if LPS and proinflammatory cytokines regulate lipin-1 in adipose tissue. LPS administration caused a marked decrease in the levels of lipin-1 mRNA in adipose tissue. This decrease occurred rapidly and lasted at least 24 h. In contrast, lipin-2 mRNA levels did not change, suggesting a specific repression of lipin-1. To determine the pathways by which LPS repressed lipin-1, we examined the effect of proinflammtory cytokines on adipocytes. In 3T3-L1 adipocytes, TNFα and IL-1β, but not LPS or IL-6, caused a decrease in lipin-1 mRNA levels. Furthermore, TNFα and IL-1β also down-regulated lipin-1 mRNA in adipose tissue in vivo. Moreover, the LPS-induced decrease in lipin-1 mRNA levels was significantly blunted in TNFα-IL-1β receptor null mice as compared to controls, suggesting that TNFα and IL-1β mediate LPS down-regulation of lipin-1. Together, our results show that lipin-1 is negatively regulated by LPS and proinflammatory cytokines, which could be a mechanism to suppress fatty acid oxidation and TG biosynthesis and thereby redirect lipids to other critical organs during the APR. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
