التفاصيل البيبلوغرافية
| العنوان: |
Proteasome blockade exerts an antifibrotic activity by coordinately down-regulating type I collagen and tissue inhibitor of metalloproteinase-1 and upregulating metalloproteinase-1 production in human dermal fibroblasts. |
| المؤلفون: |
Fineschi, Serena1, Reith, Walter2, Guerne, Pierre André3, Dayer, Jean-Michel1, Chizzolini, Carlo1 chizzolini@medecine.unige.ch |
| المصدر: |
FASEB Journal. Mar2006, Vol. 20 Issue 3, p562-564. 3p. 1 Diagram, 1 Graph. |
| مصطلحات موضوعية: |
*FIBROBLASTS, *COLLAGEN, *MESSENGER RNA, *FIBROSIS, *METALLOPROTEINASES |
| مستخلص: |
Presents findings of a study on the effects of proteosome inhibition (PI) on the biosynthetic machinery of human dermal fibroblasts in the context of fibrosis. Reduction of type I collagen and tissue inhibitor of metalloproteinase-1; Impact of PI on the level of mRNA of metalloproteinase-1 in dermal fibroblasts; Result of proteosome blockade; Role of PI in determining fibroblast viability. |
| قاعدة البيانات: |
Academic Search Index |
