التفاصيل البيبلوغرافية
| العنوان: |
Chronic intermittent hypoxia (CIH) alters respiratory behavior in the Pre-Bötzinger complex (PBC). |
| المؤلفون: |
Garcia, Alfredo J.1, Doi, Atsushi1, Hill, Andrew1, Viemari, Jean-Charles1, Prabhakar, Nanduri2, Ramirez, Jan-Marino1 |
| المصدر: |
FASEB Journal. Apr2007, Vol. 21 Issue 5, pA557-A557. 1/6p. |
| مصطلحات موضوعية: |
*HYPOXEMIA, *RESPIRATION, *RESPIRATORY organs, *OXIDATIVE stress, *PACEMAKER cells, *SLEEP apnea syndromes |
| مستخلص: |
CIH enhances the sensitivity to hypoxia and leads to hypertension, infarctions, cognitive dysfunction and sudden death in elderly. However, the direct effects of CIH on the central respiratory network remain unknown. Here we characterized the effects of CIH on the respiratory network in the PBC isolated in medullary slices from mice (up to P7). CIH was applied to newborn pups for 7 days prior to the experiments. CIH significantly altered redox and modulatory states in the isolated respiratory network. Although acute hypoxia evoked variable responses in slices from CIH-exposed animals, recovery from hypoxia was commonly delayed. Additionally, increasing oxidative stress with H2O2 (0.22 mM) prolonged recovery compared to hypoxia alone. An exaggerated long-term facilitation was seen in some, but not in all CIH-exposed animals. In the absence of cadmium-insensitive pacemakers, respiratory network activity of controls disintegrates in the presence of norepinephrine (NE, 20uM). Following CIH exposure NE evoked an apneusis-like pattern. Our data suggest that CIH alters properties of the central respiratory network and may be implicated with respiratory changes found in obstructive sleep apnea. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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