دورية أكاديمية
Strain-specific effects of rosiglitazone on bone mass, body composition, and serum insulin-like growth factor-I.
| العنوان: | Strain-specific effects of rosiglitazone on bone mass, body composition, and serum insulin-like growth factor-I. |
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| المؤلفون: | Ackert-Bicknell, Cheryl L, Shockley, K R, Horton, L G, Lecka-Czernik, B, Churchill, G A, Rosen, C J |
| المصدر: | Faculty Research 2000 - 2009 |
| بيانات النشر: | The Mouseion at the JAXlibrary |
| سنة النشر: | 2009 |
| المجموعة: | The Jackson Laboratory: The Mouseion at the JAXlibrary |
| مصطلحات موضوعية: | Animals, Body-Composition, Bone-Density, Bone-and-Bones, Female, Femur, Hypoglycemic-Agents, Insulin-Like-Growth-Factor-I, Mice-Inbred-C3H, Mice-Inbred-C57BL, Mice-Inbred-DBA, Mice-Inbred-Strains, Organ-Size, Species-Specificity, Thiazolidinediones, Life Sciences, Medicine and Health Sciences |
| الوصف: | Activation of peroxisome proliferator activated receptor-gamma (PPARG) is required for the differentiation of marrow mesenchymal stem cell into adipocytes and is associated with the development of age-related marrow adiposity in mice. Thiazolidinediones are agonists for PPARG and have a heterogeneous effect on bone mineral density (BMD). We postulated that genetic determinants influence the skeletal response to thiazolidinediones. We examined the effects of rosiglitazone (3 mg/kg . d for 8 wk) on BMD, body composition, and serum IGF-I in adult female mice from four inbred strains. C3H/HeJ mice showed the most significant response to treatment, exhibiting decreased femoral and vertebral BMD, reduced distal femoral bone volume fraction and a decrease in serum IGF-I. In DBA/2J, there were no changes in femoral BMD or bone volume fraction, but there was a decrease in vertebral BMD. C57BL/6J mice showed increases in marrow adiposity, without associated changes in trabecular bone volume; the skeletal effects from rosiglitazone in A/J mice were minimal. No association between trabecular bone volume and marrow adiposity was found. The effect of rosiglitazone on gene expression in the femur was then examined in the C3H/HeJ and C57BL/6J strains by microarray. Increased gene expression was observed in the PPARG signaling pathway and fatty acid metabolism in both C3H/HeJ and C57BL/6J, but a significant down-regulation of genes associated with cell cycle was noted only in the C3H/HeJ strain. The divergent skeletal responses to rosiglitazone in this study suggest the existence of a strong genetic background effect. |
| نوع الوثيقة: | text |
| اللغة: | unknown |
| العلاقة: | https://mouseion.jax.org/stfb2000_2009/1930Test; http://endo.endojournals.org/cgi/content/abstract/150/3/1330Test |
| الإتاحة: | https://mouseion.jax.org/stfb2000_2009/1930Test http://endo.endojournals.org/cgi/content/abstract/150/3/1330Test |
| رقم الانضمام: | edsbas.A6476087 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |