التفاصيل البيبلوغرافية
| العنوان: |
A cross-sectional study of differences in 6-min walk distance in healthy adults residing at high altitude versus sea level |
| المؤلفون: |
Fabiola León-Velarde, Lilia Cabrera, Russell Dowling, William Checkley, Talia Stewart, Antonio Bernabe-Ortiz, Robert H Gilman, Deirdre Caffrey, Robert A. Wise, Victor G. Davila-Roman, J. Jaime Miranda |
| المصدر: |
Extreme Physiology & Medicine |
| بيانات النشر: |
Springer Science and Business Media LLC, 2014. |
| سنة النشر: |
2014 |
| مصطلحات موضوعية: |
Gerontology, Physiology, blood biochemistry, spirometry, Six-minute walk test, Patient Health Questionnaire, human experiment, middle aged, heart rate, Orthopedics and Sports Medicine, Hypoxia, Oxygen saturation (medicine), education.field_of_study, medicine.diagnostic_test, purl.org/pe-repo/ocde/ford#3.01.08 [https], adult, Effects of high altitude on humans, forced expiratory volume, aged, body fat, priority journal, body height, altitude, Spirometry, Population, sea level, Article, heart protection, Altitude, male, forced vital capacity, six minute walk test, Physiology (medical), Functional capacity, Heart rate, medicine, cross-sectional study, Blood test, human, normal human, education, Sea level, High altitude adaptation, business.industry, Research, dyspnea, oxygen saturation, age, business, Demography |
| الوصف: |
Background: We sought to determine if adult residents living at high altitude have developed sufficient adaptation to a hypoxic environment to match the functional capacity of a similar population at sea level. To test this hypothesis, we compared the 6-min walk test distance (6MWD) in 334 residents living at sea level vs. at high altitude. Methods: We enrolled 168 healthy adults aged ≥35 years residing at sea level in Lima and 166 individuals residing at 3,825 m above sea level in Puno, Peru. Participants completed a 6-min walk test, answered a sociodemographics and clinical questionnaire, underwent spirometry, and a blood test. Results: Average age was 54.0 vs. 53.8 years, 48% vs. 43% were male, average height was 155 vs. 158 cm, average blood oxygen saturation was 98% vs. 90%, and average resting heart rate was 67 vs. 72 beats/min in Lima vs. Puno. In multivariable regression, participants in Puno walked 47.6 m less (95% CI -81.7 to -13.6 m; p < 0.01) than those in Lima. Other variables besides age and height that were associated with 6MWD include change in heart rate (4.0 m per beats/min increase above resting heart rate; p < 0.001) and percent body fat (-1.4 m per % increase; p = 0.02). Conclusions: The 6-min walk test predicted a lowered functional capacity among Andean high altitude vs. sea level natives at their altitude of residence, which could be explained by an incomplete adaptation or a protective mechanism favoring neuro- and cardioprotection over psychomotor activity. © Caffrey et al. |
| تدمد: |
2046-7648 |
| الوصول الحر: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2385d54124c9eddd09424bd3baeace05Test
https://doi.org/10.1186/2046-7648-3-3Test |
| حقوق: |
OPEN |
| رقم الانضمام: |
edsair.doi.dedup.....2385d54124c9eddd09424bd3baeace05 |
| قاعدة البيانات: |
OpenAIRE |
