التفاصيل البيبلوغرافية
| العنوان: |
Potential therapeutic role of statins in neurological disorders |
| المؤلفون: |
Maurizio Bifulco, Giuseppe Marasco, Anna Maria Malfitano |
| المساهمون: |
Bifulco, M., Malfitano, A. M., Marasco, G. |
| المصدر: |
Expert review of neurotherapeutics. 8(5) |
| سنة النشر: |
2008 |
| مصطلحات موضوعية: |
Angiogenesis, Inflammation, Disease, Neurological disorder, Pharmacology, Bioinformatics, Immunomodulation, chemistry.chemical_compound, Medicine, Pleiotropic effect, Humans, Pharmacology (medical), cardiovascular diseases, Primary Brain Tumors, Stroke, Nervous System Disease, Clinical Trials as Topic, Cholesterol, business.industry, General Neuroscience, Multiple sclerosis, Statin, medicine.disease, Angiogenesi, Treatment Outcome, chemistry, Neurology (clinical), Hydroxymethylglutaryl-CoA Reductase Inhibitor, medicine.symptom, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Nervous System Diseases, business, Human |
| الوصف: |
Statins, the inhibitors of HMG-CoA reductase, are currently among the most commonly prescribed agents for the prevention of cardiovascular disease. It is well established that statins reduce cholesterol levels and prevent coronary heart disease. Moreover, evidence suggests that statins have additional properties such as endothelial protection via actions on the nitric oxide synthetase system as well as antioxidant, anti-inflammatory and antiplatelet effects. There is evidence that all these actions might have potential therapeutic implications not only in stroke, but also in various neurological disorders, such as Alzheimer's disease, Parkinson's disease, multiple sclerosis and primary brain tumors. In this review, we summarize the protective effects of statins on various neurological diseases. Currently available data suggest that statins are safe and effective in the treatment of these neurological disorders, although further experiments and new data are required. © 2008 Expert Reviews Ltd. |
| تدمد: |
1744-8360 |
| الوصول الحر: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84fde63147316d73d70c479e51fd1e78Test
https://pubmed.ncbi.nlm.nih.gov/18457539Test |
| حقوق: |
CLOSED |
| رقم الانضمام: |
edsair.doi.dedup.....84fde63147316d73d70c479e51fd1e78 |
| قاعدة البيانات: |
OpenAIRE |
