التفاصيل البيبلوغرافية
| العنوان: |
The diagnostic and prognostic potential of plasma extracellular vesicles for cardiovascular disease. |
| المؤلفون: |
Bank, Ingrid EM, Timmers, Leo, Gijsberts, Crystel M, Zhang, Ya-Nan, Mosterd, Arend, Wang, Jiong-Wei, Chan, Mark Y, De Hoog, Vince, Lim, Sai Kiang, Sze, Siu Kwan, Lam, Carolyn SP, De Kleijn, Dominique PV |
| المصدر: |
Expert Review of Molecular Diagnostics; Dec2015, Vol. 15 Issue 12, p1577-1588, 12p |
| مستخلص: |
Cardiovascular disease (CVD) is the leading cause of death worldwide and its prevalence is expected to rise rapidly worldwide in the coming decades. Atherosclerosis, the syndrome underlying CVD, is a chronic progressive disease of the arteries already present at a young age. Strokes, heart attacks and heart failure are acute CVD events that occur after decades, however, and require timely diagnosis and treatment. Plasma extracellular vesicles (EVs) are microstructures with a lipid bilayer membrane involved in hemostasis, inflammation and injury. Both EV-counts and EV-content are associated with CVD and the identification of plasma EVs is a novel source of blood-based biomarkers with the potential to improve diagnosis and prognosis of CVD. Presented in this review is an overview of the current use of EVs in CVD and a discussion of the need for robust and easy isolation technologies for plasma EV subsets. This is needed to bring this promising field towards clinical application in the patient. [ABSTRACT FROM PUBLISHER] |
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| قاعدة البيانات: |
Complementary Index |
