Blood concentrations of proapoptotic sFas and antiapoptotic Bcl2 and COVID-19 patient mortality
| العنوان: | Blood concentrations of proapoptotic sFas and antiapoptotic Bcl2 and COVID-19 patient mortality |
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| المؤلفون: | Leonardo Lorente, Antonia Pérez-Cejas, María M. Martín, A. Perez, Alejandro Jiménez, Agustín F. González-Rivero, Luis Ramos-Gómez, Nazario Ojeda, José Alberto Marcos Y Ramos, Mónica Argueso, Jordi Solé-Violán |
| المصدر: | Expert Review of Molecular Diagnostics article-version (VoR) Version of Record |
| بيانات النشر: | Taylor & Francis, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Logistic regression, Gastroenterology, Pathology and Forensic Medicine, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Intensive care, Genetics, medicine, Humans, Prospective Studies, fas Receptor, Prospective cohort study, Molecular Biology, Original Research, Aged, BCl2, business.industry, High serum, COVID-19, sFas, Serum concentration, Middle Aged, mortality, Icu admission, Intensive Care Units, 030104 developmental biology, COVID-19: patients, Antiapoptotic protein, Proto-Oncogene Proteins c-bcl-2, 030220 oncology & carcinogenesis, Area Under Curve, Molecular Medicine, Female, business, Biomarkers, Research Article |
| الوصف: | Background: There are no data on circulating concentrations of sFas (proapoptotic protein of extrinsic pathway) and Bcl2 (antiapoptotic protein of intrinsic pathway) in COVID-19 patients. Thus, our objective study was to determine whether an association exists between serum concentrations of sFas and Bcl2 and COVID-19 patient mortality. Methods: This observational and prospective study of COVID-19 patients was performed in eight Intensive Care Units (ICU) from Canary Islands (Spain). Serum levels of sFas and Bcl2 at ICU admission were determined. Mortality at 30 days was the end-point study. Results: Surviving patients (n = 42) compared to non-surviving (n = 11) had lower APACHE-II (p |
| اللغة: | English |
| تدمد: | 1744-8352 1473-7159 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5492b4c68ff6883a2f09811820fcd91fTest http://europepmc.org/articles/PMC8240540Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5492b4c68ff6883a2f09811820fcd91f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17448352 14737159 |
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