Intravenous immunoglobulin use for Stevens–Johnson syndrome in children
| العنوان: | Intravenous immunoglobulin use for Stevens–Johnson syndrome in children |
|---|---|
| المؤلفون: | Aleda A Jacobs, Moise L. Levy, Christy Badgwell, Denise W. Metry |
| المصدر: | Expert Review of Dermatology. 1:563-567 |
| بيانات النشر: | Informa UK Limited, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | medicine.medical_specialty, integumentary system, biology, business.industry, Disease spectrum, Stevens johnson, Dermatology, Keratinocyte apoptosis, medicine.disease, High fever, Toxic epidermal necrolysis, Malaise, stomatognathic diseases, Immunology, Sore throat, medicine, biology.protein, medicine.symptom, Antibody, business |
| الوصف: | Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis are severe cutaneous reactions that carry significant morbidity risks, and in more serious cases also mortality risks, for those affected. Overlap exists between SJS and toxic epidermal necrolysis, which most experts agree are part of the same disease spectrum. Both are most commonly precipitated by drugs and generally begin with a prodrome of high fever, sore throat and malaise, followed by the rapid onset of cutaneous blistering. Immune-mediated keratinocyte apoptosis or programmed cell death precedes the epidermal detachment that occurs in SJS and toxic epidermal necrolysis, although, by definition, it is more focal in SJS. Both conditions are also characterized by epidermal detachment in addition to mucosal involvement, although the development of large sheets of epidermal detachment in the absence of mucosal involvement is more characteristic of toxic epidermal necrolysis. However, the frequent presence of overlapping clinical features in ... |
| تدمد: | 1746-9880 1746-9872 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::187ec47eafb6ee036707d3e9258a7cd4Test https://doi.org/10.1586/17469872.1.4.563Test |
| رقم الانضمام: | edsair.doi...........187ec47eafb6ee036707d3e9258a7cd4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17469880 17469872 |
|---|