Add-on manidipine versus amlodipine in diabetic patients with hypertension and microalbuminuria: the AMANDHA study
| العنوان: | Add-on manidipine versus amlodipine in diabetic patients with hypertension and microalbuminuria: the AMANDHA study |
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| المؤلفون: | Francisco Javier Martinez-Martin, Margarita Saiz-Satjes |
| المصدر: | Expert Review of Cardiovascular Therapy. 6:1347-1355 |
| بيانات النشر: | Informa UK Limited, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Adult, Male, Dihydropyridines, medicine.medical_specialty, Urology, Angiotensin-Converting Enzyme Inhibitors, Blood Pressure, Piperazines, Renin-Angiotensin System, Excretion, Manidipine, Diabetes mellitus, Internal Medicine, medicine, Albuminuria, Humans, Prospective Studies, Amlodipine, Prospective cohort study, Antihypertensive Agents, Nitrobenzenes, Aged, business.industry, General Medicine, Middle Aged, Calcium Channel Blockers, medicine.disease, Blood pressure, Diabetes Mellitus, Type 2, Decreased blood pressure, Hypertension, Drug Therapy, Combination, Female, Microalbuminuria, Cardiology and Cardiovascular Medicine, business, Angiotensin II Type 1 Receptor Blockers, Follow-Up Studies, medicine.drug |
| الوصف: | The aim of this study was to compare the efficacy and safety of adding manidipine 20 mg versus amlodipine 10 mg to the treatment of diabetic patients with uncontrolled hypertension and microalbuminuria despite full-dose treatment with a renin-angiotensin system blocker for at least 6 months. Patients were randomized to receive manidipine (n = 61) or amlodipine (n = 30) in a 2:1 ratio for 6 months and monitored for microalbuminuria for an additional extension phase of 18 months. Manidipine and amlodipine decreased blood pressure values to a similar extent. Urinary albumin excretion was reduced by 65.5% with manidipine versus 20% with amlodipine (p < 0.01) at 6 months and 62.7 versus 16.6% (p < 0.01) at the end of the extension phase. Manidipine was better tolerated than amlodipine. Thus, the addition of manidipine, but not amlodipine, resulted in a large reduction in the urinary albumin excretion rate despite similar blood pressure reductions. |
| تدمد: | 1744-8344 1477-9072 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5410d2e8114c58b6567a3c17e987d7a2Test https://doi.org/10.1586/14779072.6.10.1347Test |
| رقم الانضمام: | edsair.doi.dedup.....5410d2e8114c58b6567a3c17e987d7a2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17448344 14779072 |
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