Targeting the 5′-AMP-activated protein kinase and related metabolic pathways for the treatment of prostate cancer
| العنوان: | Targeting the 5′-AMP-activated protein kinase and related metabolic pathways for the treatment of prostate cancer |
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| المؤلفون: | Daniel E. Frigo, Petra Popovics, Ferenc G. Rick, Andrew V. Schally |
| المصدر: | Expert Opinion on Therapeutic Targets. 19:617-632 |
| بيانات النشر: | Informa UK Limited, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, Clinical Biochemistry, Antineoplastic Agents, Calcium-Calmodulin-Dependent Protein Kinase Kinase, AMP-Activated Protein Kinases, Prostate cancer, Drug Discovery, medicine, Animals, Humans, ASK1, Molecular Targeted Therapy, Protein kinase A, CAMKK2, Pharmacology, biology, Akt/PKB signaling pathway, Cyclin-dependent kinase 4, Cyclin-dependent kinase 2, Prostatic Neoplasms, AMPK, medicine.disease, Cell biology, Drug Design, Androgens, biology.protein, Molecular Medicine, Signal Transduction |
| الوصف: | Increasing evidence suggests that prostate cancer cells undergo unique metabolic reprogramming during transformation. A master regulator of cellular homeostasis, 5'-AMP-activated protein kinase (AMPK), directs metabolic adaptation that supports the growth demands of rapidly dividing cancer cells. The utilization of AMPK as a therapeutic target may therefore provide an effective strategy in the treatment of prostate cancer.Our review describes the regulation of AMPK by androgens and upstream kinases including the calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) in prostate cancer. Oncogenic, AMPK-regulated pathways that direct various metabolic processes are also addressed. Furthermore, we discuss the role of AMPK in growth arrest and autophagy as a potential survival pathway for cancer cells. In addition, by regulating non-metabolic pathways, AMPK may stimulate migration and mitosis. Finally, this review summarizes efforts to treat prostate cancer with pharmacological agents capable of modulating AMPK signaling.Current research is primarily focused on developing drugs that activate AMPK as a treatment for prostate cancer. However, oncogenic aspects of AMPK signaling calls for caution about employing such therapies. We think that inhibitors of CaMKK2 or AMPK, or perhaps the modulation of downstream targets of AMPK, will gain importance in the clinical management of prostate cancer. |
| تدمد: | 1744-7631 1472-8222 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afb91c269c0618b9ac38d5e3e19900a3Test https://doi.org/10.1517/14728222.2015.1005603Test |
| رقم الانضمام: | edsair.doi.dedup.....afb91c269c0618b9ac38d5e3e19900a3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17447631 14728222 |
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