MicroRNAs as therapeutic targets in atherosclerosis
| العنوان: | MicroRNAs as therapeutic targets in atherosclerosis |
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| المؤلفون: | Ziad Mallat, Chantal M. Boulanger, Alain Tedgui, Xavier Loyer |
| المصدر: | Expert Opinion on Therapeutic Targets. 19:489-496 |
| بيانات النشر: | Informa Healthcare, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Cell type, Endothelium, Clinical Biochemistry, Cell, Inflammation, Biology, chemistry.chemical_compound, Drug Discovery, microRNA, Gene expression, medicine, Animals, Humans, Antagomir, RNA Processing, Post-Transcriptional, Pharmacology, Endothelial Cells, Atherosclerosis, Phenotype, Disease Models, Animal, MicroRNAs, medicine.anatomical_structure, Gene Expression Regulation, chemistry, Drug Design, Immunology, Disease Progression, Cancer research, Molecular Medicine, medicine.symptom |
| الوصف: | Atherosclerosis is a chronic inflammatory disease of the arterial wall. A number of phenotypic cell changes occur during the development and progression of atherosclerosis. MicroRNAs (miRNAs) are key regulators of gene expression that act at the post-transcriptional level. They have been implicated in cardiovascular diseases, including atherosclerosis.This review provides an overview of our knowledge about the expression and the roles of miRNAs in different cell types involved in atherosclerosis, with a focus on experimental strategies to modulate miRNA expression and their therapeutic effects in animal models of atherosclerosis. miRNA expression is regulated by inflammatory conditions and by shear stress in endothelial cells. Therapeutic approaches using antagomiR and miRNA mimic delivery and have been shown potentially effective in atherosclerosis. Moreover, a large body of evidence exists supporting a role for not only intracellular miRNA, but also miRNA carried by extracellular vesicles that are involved in inter-cellular communication through the transfer of miRNA.Modulation of miRNA expression could represent novel innovative therapeutic approaches to treat atherosclerosis by targeting a single cell type or specific pathways. Future challenges will consist in deciphering the mechanisms involved in miRNA regulation and in improving cell-specific delivery of 'miR-drugs' by alternative strategies, including miRNA-enriched micro vesicles. |
| تدمد: | 1744-7631 1472-8222 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b0589176e030b7b0ae4204eadda691dTest https://doi.org/10.1517/14728222.2014.989835Test |
| رقم الانضمام: | edsair.doi.dedup.....5b0589176e030b7b0ae4204eadda691d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17447631 14728222 |
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