Advances in the drug management of basal cell carcinoma
| العنوان: | Advances in the drug management of basal cell carcinoma |
|---|---|
| المؤلفون: | Ramelyte, Egle, Restivo, Gaetana, Mannino, Maria, Levesque, Mitchell P, Dummer, Reinhard |
| المساهمون: | University of Zurich, Ramelyte, Egle |
| المصدر: | Expert Opinion on Pharmacotherapy. 23:573-582 |
| بيانات النشر: | Informa UK Limited, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Pharmacology, 3004 Pharmacology, Skin Neoplasms, Carcinoma, Basal Cell, Tumor Microenvironment, 10177 Dermatology Clinic, 2736 Pharmacology (medical), Humans, 610 Medicine & health, Antineoplastic Agents, Pharmacology (medical), General Medicine |
| الوصف: | Basal cell carcinoma (BCC) is the most common skin cancer in humans. Recently, BCCs were suggested to be classified into 'easy to treat' and 'difficult to treat,' and different therapeutic options are suggested for their management.In this review, the authors discuss treatment options that are approved, recommended for, or are still in development for treatment of BCC. The review covers approved local therapies, such as imiquimod and 5-fluorouracil, and systemic therapies, such as hedgehog inhibitors. New medical agents, investigated in clinical trials, are reviewed. These include: targeted therapies, such as GLI antagonists or anti-VEGFR agents, immunotherapies, such as checkpoint inhibitors, recombinant cytokines or silencing RNA, as well as intralesional virotherapies with modified adeno- or herpes viruses.The progress made in recent years has improved the management of patients with advanced BCC; however, neither tumor targeting nor immune system engaging agents provide a cure. New treatment approaches directed not only to known targets but also the tumor microenvironment are in development and are anticipated to improve the management of difficult to treat BCC. |
| وصف الملف: | 932_Ramelyte_E._et_al._Advances_in_the_drug_management_of_basal_cell_carcinoma_Expert_Opinion_on_Pharmacotherapy_2022.pdf - application/pdf |
| تدمد: | 1744-7666 1465-6566 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af4aeca489f85d01a381725f981fa70aTest https://doi.org/10.1080/14656566.2022.2032646Test |
| حقوق: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....af4aeca489f85d01a381725f981fa70a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17447666 14656566 |
|---|