التفاصيل البيبلوغرافية
| العنوان: |
GnRH agonists and antagonists in therapy of symptomatic uterine fibroids – current roles and future perspectives. |
| المؤلفون: |
Ciebiera, Michał, Madueke-Laveaux, Obianuju Sandra, Feduniw, Stepan, Ulin, Mara, Spaczyński, Robert, Zgliczyńska, Magdalena, Bączkowska, Monika, Zarychta, Elżbieta, Łoziński, Tomasz, Ali, Mohamed, Al-Hendy, Ayman |
| المصدر: |
Expert Opinion on Pharmacotherapy; 2023, Vol. 24 Issue 16, p1799-1809, 11p |
| مستخلص: |
Uterine fibroids are the most common noncancerous tumors in women of childbearing age. This review was developed to evaluate the current role of gonadotropin-releasing hormone (GnRH) agonists and antagonists in the therapy of symptomatic uterine fibroids. There is a great need for alternative methods for surgical treatment of uterine fibroids. Hormonal therapy remains the first-line treatment option for most patients. GnRH analogs (agonists and antagonists) modulate the pulsatile release of GnRH. This review summarizes the available literature concerning pharmacologic principles underlying the mechanism of action of GnRH and its analogs, as well as individual therapeutic applications to which these drugs have been applied. In many cases, it is possible to try to treat uterine fibroids pharmacologically. Both groups of GnRH analogs are used in therapy, agonists instead as a preparation for surgery, and antagonists as a drug for long-term use. It is essential to develop this path further and look for at least long-term-release systems or new methods of administering these drugs. It is also important from the patient's perspective to search for possible drugs that may have an additive effect of decreasing side effects when combined with GnRH analogs. [ABSTRACT FROM AUTHOR] |
|
Copyright of Expert Opinion on Pharmacotherapy is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
