دورية
Can binimetinib, encorafenib and masitinib be more efficacious than currently available mutation-based targeted therapies for melanoma treatment?
| العنوان: | Can binimetinib, encorafenib and masitinib be more efficacious than currently available mutation-based targeted therapies for melanoma treatment? |
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| المؤلفون: | Turner, Megan C, Rossfeld, Kara, Salama, April K.S, Tyler, Douglas, Beasley, Georgia |
| المصدر: | Expert Opinion on Pharmacotherapy; March 2017, Vol. 18 Issue: 5 p487-495, 9p |
| مستخلص: | ABSTRACTIntroduction: Historically, there were few effective and durable treatments for metastatic melanoma. Recently, mutation based targeted therapies have revolutionized treatment and outcomes for patients with metastatic melanoma. Specifically, inhibitors aimed at BRAF, NRAS, and C-KITmutations are now commonly used in treatment for patients harboring the specific mutations.Areas covered: A brief review of current BRAF, NRAS, and C-KIT inhibitors provides background for a thorough review of newly developed agents namely binimetinib, a MEK inhibitor, encorafenib a BRAF inhibitor, and masitinib which inhibits C-KIT.Expert opinion: While the 3 novel agents reviewed here have potential for use in melanoma, optimal utilization will occur once a more personalized approach incorporating genomic, proteomic, and immunologic data guides therapeutic decisions. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 14656566 17447666 |
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| DOI: | 10.1080/14656566.2017.1299710 |