Recent advances on structural modifications of benzothiazoles and their conjugate systems as potential chemotherapeutics
| العنوان: | Recent advances on structural modifications of benzothiazoles and their conjugate systems as potential chemotherapeutics |
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| المؤلفون: | Srikanth Yellamelli Valli Venkata, Naseer Ahmed Khan Mohammed, Kashi Reddy Methuku, Kamal Ahmed, Farheen Sultana |
| المصدر: | Expert Opinion on Investigational Drugs. 21:619-635 |
| بيانات النشر: | Informa Healthcare, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Pharmacology, Molecular Structure, Bicyclic molecule, Antineoplastic Agents, General Medicine, chemistry.chemical_compound, Benzothiazole, chemistry, Biological profile, Neoplasms, Biological property, Animals, Humans, Moiety, Organic chemistry, Pharmacology (medical), Benzothiazoles, Pharmacophore, Heterocyclic derivatives, Conjugate |
| الوصف: | Benzothiazole scaffold comprises a bicyclic ring system and is known to exhibit a wide range of biological properties including antimicrobial and anticancer activities. Benzothiazole derivatives have long been therapeutically used for the treatment of various diseases. However, in recent years, 2-arylbenzothiazoles have emerged as an important pharmacophore in the development of antitumor agents. The promising biological profile and synthetic accessibility have been attractive in the design and development of new benzothiazoles and their conjugate systems as potential chemotherapeutics.This review mainly focuses on the structural modifications of benzothiazole scaffold, development of various series of benzothiazoles and their conjugates as new antitumor agents. Furthermore, heterocyclic derivatives bearing benzothiazole moiety and their in vitro as well as in vivo screening, structure-activity relationships (SAR), mechanism, pharmacokinetics, clinical use and their future therapeutic applications are discussed here.A large number of benzothiazole derivatives discussed here possess potent anticancer activity and can be further developed as drug candidates. Benzothiazole conjugates could also display synergistic effect and still there is a need to use the drug combinations permitting lower dose and development of new generation of drugs. Despite encouraging results that have been observed for their response to tumor in clinical studies, full characterization of their toxicity is further required for their clinical usage as safe drugs for the treatment of cancer. We believe that this review gives a better understanding and scope for future drug design and development of benzothiazole-based compounds to implicate their use in cancer chemotherapy. |
| تدمد: | 1744-7658 1354-3784 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4353d34da8973488fceb1adfa5c49713Test https://doi.org/10.1517/13543784.2012.676043Test |
| رقم الانضمام: | edsair.doi.dedup.....4353d34da8973488fceb1adfa5c49713 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17447658 13543784 |
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