INTERSECTION BETWEEN GENES CONTROLLING VASCULARIZATION AND ANGIOGENESIS IN RENAL CELL CARCINOMAS
| العنوان: | INTERSECTION BETWEEN GENES CONTROLLING VASCULARIZATION AND ANGIOGENESIS IN RENAL CELL CARCINOMAS |
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| المؤلفون: | Serhiy Souchelnytskyi |
| المصدر: | Experimental Oncology. 40:140-143 |
| بيانات النشر: | LLC MORION, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Cancer Research, Angiogenesis, Cell, Computational biology, Biology, Kidney Neoplasms/pathology, angiogenesis, 03 medical and health sciences, 0302 clinical medicine, Text mining, vascularization, Intersection, Carcinoma, Renal Cell/genetics, Neovascularization, Pathologic/genetics, medicine, cancer, Humans, Carcinoma, Renal Cell, Gene, Systemic analysis, Neovascularization, Pathologic, business.industry, Gene Expression Profiling, Computational Biology, Molecular Sequence Annotation, Carcinoma, Renal Cell/pathology, Computational Biology/methods, systemic analysis, Short communications, Kidney Neoplasms, Gene Expression Regulation, Neoplastic, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Identification (biology), Transcriptome, business |
| الوصف: | Aim: To show that application of the systemic analysis may significantly improve comparison of different datasets. Different genes and proteins may converge on the same functional outputs. A comparison of 2 datasets by only identification names of affected molecules may miss that, leading to a conclusion that there is nothing in common for these datasets. Systemic analysis may overcome this limitation, by focusing on functions represented by the identification names. Materials and Methods: Datasets were retrieved from open sources. Systemic analysis of vascularization features and angiogenesis signature was performed by using Cytoscape and its plugs-in. Results: In contrary to the initial statement of the lack of overlap between the vascularization features and the angiogenesis genes-signature in renal carcinomas, we observed an intersection on the functional level. Analysis of the networks built with identification names of vascularization and angiogenesis datasets showed an intersection, which included potent regulators of vessel formation and growth. Conclusion: Analysis of networks may expose functional links, which may be missed by a direct identification names comparison. Key Words: cancer, vascularization, angiogenesis, systemic analysis. |
| تدمد: | 2312-8852 1812-9269 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8019e035b69cd8d8ede216e3104cd787Test https://doi.org/10.31768/2312-8852.2018.40Test(2):140-143 |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8019e035b69cd8d8ede216e3104cd787 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23128852 18129269 |
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